Cystic fibrosis pathology and 4-phenylbutyrate (HG-U133A)
Summary:
Effect of 1mM 4-phenylbutyrate (PBA) at 0, 12 and 24 hours in cystic fibrosis bronchial epithelial model cell line IB3-1. PBA modulates heat shock protein and promotes trafficking of deltaF508 cystic fibrosis transmembrane conductance regulator (CFTR).
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Wright JM, Zeitlin PL, Cebotaru L, Guggino SE et al. Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins. Physiol Genomics 2004 Jan 15;16(2):204-11. PMID: 14583596
