17β-estradiol effect on breast adenocarcinoma cells deficient in extracellular signal-regulated kinase 5
Summary:
Analysis of MCF-7 breast cancer (BC) cells depleted for ERK5 then treated with 17β-estradiol. Increased kinase activity is associated with a poorer outcome for BC patients. Results provide insight into the interplay between estrogen receptor and protein kinase pathways to regulate BC aggressiveness
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Madak-Erdogan Z, Ventrella R, Petry L, Katzenellenbogen BS. Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer. Mol Cancer Res 2014 May;12(5):714-27. PMID: 24505128
