Analysis of lung up to 25 hrs after a single, intratracheal administration of mepenzolate (MEP). MEP, a muscarinic receptor antagonist, decreases elastase-induced airspace enlargement. Results provide insight into molecular mechanisms underlying the beneficial effect of MEP on airspace enlargement.
Tanaka K, Ishihara T, Sugizaki T, Kobayashi D et al. Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease. Nat Commun 2013;4:2686. PMID: 24189798