Conventional cigarette or modified-risk tobacco product smoke effect on lung bronchial epithelium: dose response
Summary:
Analysis of left lung bronchi from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.
GPL1355:
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Citation:
Kogel U, Schlage WK, Martin F, Xiang Y et al. A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes. Food Chem Toxicol 2014 Jun;68:204-17. PMID: 24632068
