Pirin depletion effect on myelomonocytic cell line
Summary:
Analysis of U937 myelomonocytic cells depleted for Pirin. Pirin is silenced in cells with the acute myeloid leukemia-1 eight-twenty-one and promyelocytic leukemia/retinoic acid receptor leukemogenic fusion proteins. Results provide insight into the role of Pirin in myeloid differentiation.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Licciulli S, Cambiaghi V, Scafetta G, Gruszka AM et al. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Leukemia 2010 Feb;24(2):429-37. PMID: 20010624
