Analysis of forebrain from male and female E12.5 embryos heterozygous for the Meis1tm1Mtor allele. These animals express only one functional allele of Meis1, modeling the reduced expression of MEIS1 in Restless Legs Syndrome (RLS) patients. Results provide insight the role of MEIS1 in RLS.
Spieler D, Kaffe M, Knauf F, Bessa J et al. Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res 2014 Apr;24(4):592-603. PMID: 24642863
