Edelfosine effect on unstimulated CD4+ T cells: dose response
Summary:
Analysis of unstimulated CD4+ T cells (derived from buffy coat PBMCs) treated with edelfosine at 3.3 or 10 µg/ml. Edelfosine is a cytotoxic drug taken up by highly proliferating cells such as activated immune cells. Results provide insight into molecular basis of edelfosine action in immune Tcells.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Abramowski P, Otto B, Martin R. The orally available, synthetic ether lipid edelfosine inhibits T cell proliferation and induces a type I interferon response. PLoS One 2014;9(3):e91970. PMID: 24667731
