DEK oncogene deficiency effect in U937 leukemic monocyte lymphoma cells
Summary:
Analysis of U937 cells following DEK oncogene knockdown by two different shRNAs (shDEK14, shDEK17). The DEK gene is highly expressed in many types of cancer cells and involved in chromosomal translocation in acute myelogenous leukemia. Results provide insight into the role of DEK in gene regulation.
Sandén C, Järvstråt L, Lennartsson A, Brattås PL et al. The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation. Mol Cancer 2014 Sep 12;13:215. PMID: 25216995
