Analysis of kidney tumors from Lin28a transgenics at 5 weeks and 4 months of age. Overexpression of heterochronic regulator Lin28 during kidney development promotes Wilms tumor formation. Results provide insight into the role of Lin28 in Wilms tumor formation.
Urbach A, Yermalovich A, Zhang J, Spina CS et al. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev 2014 May 1;28(9):971-82. PMID: 24732380