Analysis of splenocytes from WT, B6.Sle1.Sle3 (lupus mice) and B6.Sle1.Sle3 Tcf4+/− (Sle/het) mice haplodeficient for the transcription factor E2-2 (Tcf4). E2-2 is a specific regulator of plasmacytoid dendritic cell (pDC) development. Results provide insight into role of pDC in SLE pathogenesis.
Sisirak V, Ganguly D, Lewis KL, Couillault C et al. Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. J Exp Med 2014 Sep 22;211(10):1969-76. PMID: 25180061