Metastatic breast cancer model: premetastatic lung
Summary:
Analysis of premetastatic lung from BALB/c mice without any tumors (naïve) and from mice bearing nonmetastatic (67NR) or metastatic (4T1) breast carcinomas. Results provide insight into metastatic tumor-induced molecular changes in premetastatic lungs before the arrival of metastatic tumor cells.
Kowanetz M, Wu X, Lee J, Tan M et al. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A 2010 Dec 14;107(50):21248-55. PMID: 21081700