Interferon-gamma effect on lipopolysaccharide-activated bone marrow-derived macrophages
Summary:
Analysis of BMDMs primed with IFNγ and subsequently activated with LPS. Pro-inflammatory macrophages are induced by the Th1 cytokine IFNγ and/or the toll-like receptor ligand LPS. Results provide insight into the molecular effects of IFNγ priming on LPS-induced inflammation in macrophages.
Hoeksema MA, Scicluna BP, Boshuizen MC, van der Velden S et al. IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment. J Immunol 2015 Apr 15;194(8):3909-16. PMID: 25750432
