Circadian nuclear receptor REV-ERBα deficiency effect on ventral midbrain
Summary:
Analysis of ventral midbrain (VMB) from Rev-erbα knock-outs that were entrained under a 12hr light-dark photoperiod for >10 days, kept in darkness for 2 days, and sacrificed on the third day. REV-ERBα is associated with bipolar disorder. Results provide insight into the role of REV-ERBα in VMB.
Chung S, Lee EJ, Yun S, Choe HK et al. Impact of circadian nuclear receptor REV-ERBα on midbrain dopamine production and mood regulation. Cell 2014 May 8;157(4):858-68. PMID: 24813609
