Double-knockout p53/PRKDC model of B cell acute lymphoblastic leukemia: leukemic blasts
Summary:
Analysis of leukemic blasts from p53/Prkdc double-knockout mutants that spontaneously develop early B cell acute lymphoblastic leukemia (B-ALL). Results provide insight into molecular mechanisms underlying high-risk B-ALL.
Perova T, Grandal I, Nutter LM, Papp E et al. Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia. Sci Transl Med 2014 May 14;6(236):236ra62. PMID: 24828076