Cultured primary lung fibroblasts incubated 4 hours in the presence or absence of 100 nM endothelin-1 (ET-1). Results suggest that ET-1 is involved in matrix synthesis and connective tissue deposition during wound repair and in pulmonary fibrosis.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Xu SW, Howat SL, Renzoni EA, Holmes A et al. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 2004 May 28;279(22):23098-103. PMID: 15044479
