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    ATP7A ATPase copper transporting alpha [ Equus caballus (horse) ]

    Gene ID: 100071762, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ATP7Aprovided by VGNC
    Official Full Name
    ATPase copper transporting alphaprovided by VGNC
    Primary source
    VGNC:VGNC:15684
    See related
    Ensembl:ENSECAG00000016767
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) X NC_009175.3 (60884324..61016956)

    Chromosome X - NC_009175.3Genomic Context describing neighboring genes Neighboring gene magnesium transporter 1 Neighboring gene cytochrome c oxidase subunit 7B Neighboring gene high mobility group protein B1 pseudogene Neighboring gene uncharacterized LOC100072664 Neighboring gene phosphoglycerate kinase 1 Neighboring gene TATA-box binding protein associated factor 9b

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009175.3 Chromosome X Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables P-type divalent copper transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in copper ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copper-transporting ATPase 1
    Names
    ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)
    Menkes syndrome protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009175.3 Reference EquCab3.0 Primary Assembly

      Range
      60884324..61016956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014728991.2 → XP_014584477.1  copper-transporting ATPase 1 isoform X2

      UniProtKB/TrEMBL
      A0A9L0SYL0
      Related
      ENSECAP00000015148.3, ENSECAT00000018565.3
      Conserved Domains (4) summary
      cd00371
      Location:380 → 443
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      TIGR01511
      Location:727 → 1371
      ATPase-IB1_Cu; copper-(or silver)-translocating P-type ATPase
      pfam00122
      Location:786 → 1033
      E1-E2_ATPase; E1-E2 ATPase
      cl21460
      Location:1180 → 1323
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. XM_005614286.3 → XP_005614343.1  copper-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A9L0SAF1, A0A9L0SYL0
      Related
      ENSECAP00000073118.1, ENSECAT00000118893.1
      Conserved Domains (4) summary
      cd00371
      Location:380 → 443
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      TIGR01511
      Location:727 → 1389
      ATPase-IB1_Cu; copper-(or silver)-translocating P-type ATPase
      pfam00122
      Location:786 → 1033
      E1-E2_ATPase; E1-E2 ATPase
      cl21460
      Location:1198 → 1341
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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