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    Cxcr6 C-X-C motif chemokine receptor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100124593, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cxcr6provided by RGD
    Official Full Name
    C-X-C motif chemokine receptor 6provided by RGD
    Primary source
    RGD:1642118
    See related
    Ensembl:ENSRNOG00000006319 AllianceGenome:RGD:1642118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chemokine binding activity and chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CXCR6 (C-X-C motif chemokine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See Cxcr6 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (132311834..132317001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (123434417..123439568)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132869712..132870766)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 9 Neighboring gene FYVE and coiled-coil domain autophagy adaptor 1 Neighboring gene basic leucine zipper and W2 domains 1, pseudogene 2 Neighboring gene X-C motif chemokine receptor 1 Neighboring gene CDK2-associated, cullin domain 1, pseudogene 1 Neighboring gene transcription initiation factor TFIID subunit 13-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis. Latta M, et al. Immunology, 2007 Aug. PMID 17437534, Free PMC Article
    2. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Matloubian M, et al. Nat Immunol, 2000 Oct. PMID 11017100
    3. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Rabquer BJ, et al. Arthritis Res Ther, 2011 Feb 8. PMID 21303517, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-X-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables C-X-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C-X-C chemokine receptor type 6
    Names
    chemokine (C-X-C motif) receptor 6
    chemokine receptor CXCR6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102587.2 → NP_001096057.1  C-X-C chemokine receptor type 6

      See identical proteins and their annotated locations for NP_001096057.1

      Status: VALIDATED

      Source sequence(s)
      DQ132631, JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A6M4C4C7, A0A6M4C4D9, A0A6M4C4J1, A0A6M4C4K1, A0A6M4C534, A7ISD5
      Conserved Domains (2) summary
      cd14964
      Location:41 → 68
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:41 → 307
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      132311834..132317001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080642.2 → XP_038936570.1  C-X-C chemokine receptor type 6 isoform X1

      UniProtKB/TrEMBL
      A0A6M4C4C7, A0A6M4C4D9, A0A6M4C4J1, A0A6M4C4K1, A0A6M4C534, A6I4C7, F7F415
      Related
      ENSRNOP00000008294.2
      Conserved Domains (2) summary
      cd14964
      Location:44 → 71
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:44 → 310
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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