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    TSPY10 testis specific protein Y-linked 10 [ Homo sapiens (human) ]

    Gene ID: 100289087, updated on 17-Jun-2024

    Summary

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    Official Symbol
    TSPY10provided by HGNC
    Official Full Name
    testis specific protein Y-linked 10provided by HGNC
    Primary source
    HGNC:HGNC:37473
    See related
    Ensembl:ENSG00000236424 AllianceGenome:HGNC:37473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT78; TSPY; TSPY1; TSPY3
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in sex differentiation. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 37.7) See more
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    Genomic context

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    See TSPY10 in Genome Data Viewer
    Location:
    Yp11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (9527880..9530676)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (9755329..9758125)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9365489..9368285)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein Y-linked 6, pseudogene Neighboring gene family with sequence similarity 197 Y-linked member 2 Neighboring gene testis specific protein Y-linked 15, pseudogene Neighboring gene RNA binding motif protein Y-linked family 3 member A, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Skaletsky H, et al. Nature, 2003 Jun 19. PMID 12815422
    2. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ98219, MGC103998, MGC150414

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific Y-encoded protein 10
    Names
    Cancer/testis antigen 78
    Testis-specific Y-encoded protein 1
    Testis-specific Y-encoded protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282469.3 → NP_001269398.1  testis-specific Y-encoded protein 10 isoform 1

      See identical proteins and their annotated locations for NP_001269398.1

      Status: VALIDATED

      Source sequence(s)
      BC121114, DB545400
      Consensus CDS
      CCDS65365.1
      UniProtKB/Swiss-Prot
      P0CV98, P0CW01
      UniProtKB/TrEMBL
      Q540R4
      Related
      ENSP00000406407.2, ENST00000428845.6
      Conserved Domains (1) summary
      cl08298
      Location:126 → 288
      NAP; Nucleosome assembly protein (NAP)

    2. NM_001320962.1 → NP_001307891.1  testis-specific Y-encoded protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC006156
      Consensus CDS
      CCDS83519.1
      UniProtKB/TrEMBL
      F2Z2I4, Q540R4
      Related
      ENSP00000397151.1, ENST00000444056.1
      Conserved Domains (1) summary
      cl08298
      Location:103 → 273
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      9527880..9530676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017030025.2 → XP_016885514.1  testis-specific Y-encoded protein 10 isoform X1

    RNA

    1. XR_001756003.2 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791821.1 Reference GRCh38.p14 PATCHES

      Range
      752540..755334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333413.1 → XP_054189388.1  testis-specific Y-encoded protein 10 isoform X1

    RNA

    1. XR_008485837.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      9755329..9758125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328240.1 → XP_054184215.1  testis-specific Y-encoded protein 10 isoform X1

    RNA

    1. XR_008485522.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CW01.2 GenPept UniProtKB/Swiss-Prot:P0CW01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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