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    SPDYE2B speedy/RINGO cell cycle regulator family member E2B [ Homo sapiens (human) ]

    Gene ID: 100310812, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPDYE2Bprovided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E2Bprovided by HGNC
    Primary source
    HGNC:HGNC:48334
    See related
    Ensembl:ENSG00000173678 AllianceGenome:HGNC:48334
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPDYE2L
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 4.5), spleen (RPKM 2.9) and 25 other tissues See more
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    Genomic context

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    See SPDYE2B in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102650319..102662625)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103962083..103974433)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102290766..102303072)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901714 Neighboring gene RAS p21 protein activator 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102250895-102251509 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102252774-102253416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102253600-102254568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102255538-102256506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102264455-102264956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102264957-102265456 Neighboring gene POLR2J2-UPK3BL1 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102281267-102281768 Neighboring gene uroplakin 3B like 1 Neighboring gene RNA polymerase II subunit J2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102321101-102321878 Neighboring gene uncharacterized LOC124901713 Neighboring gene RAS p21 protein activator 4D, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
    2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    speedy protein E2B
    Names
    WBSCR19-like protein 3
    putative WBSCR19-like protein 3
    putative speedy protein E2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166339.2 → NP_001159811.1  speedy protein E2B

      See identical proteins and their annotated locations for NP_001159811.1

      Status: VALIDATED

      Source sequence(s)
      AC105052
      Consensus CDS
      CCDS59507.1
      UniProtKB/Swiss-Prot
      A6NHP3, D6RBN0
      Related
      ENSP00000424058.1, ENST00000507450.6
      Conserved Domains (1) summary
      pfam11357
      Location:194 → 398
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      102650319..102662625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515702.4 → XP_011514004.1  speedy protein E2B isoform X1

      Conserved Domains (1) summary
      pfam11357
      Location:194 → 303
      Spy1; Cell cycle regulatory protein

    2. XM_047419693.1 → XP_047275649.1  speedy protein E2B isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      103962083..103974433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356967.1 → XP_054212942.1  speedy protein E2B isoform X3

    2. XM_054356968.1 → XP_054212943.1  speedy protein E2B isoform X2

    3. XM_054356966.1 → XP_054212941.1  speedy protein E2B isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NHP3.2 GenPept UniProtKB/Swiss-Prot:A6NHP3

    Gene LinkOut

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