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    Kr-h1 Kruppel homolog 1 [ Bombyx mori (domestic silkworm) ]

    Gene ID: 100415910, updated on 10-Oct-2024

    Summary

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    Gene symbol
    Kr-h1
    Gene description
    Kruppel homolog 1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bombyx mori
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
    Also known as
    BmKr-h1
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    Genomic context

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    See Kr-h1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 4 NC_085110.1 (12831230..12840096, complement)
    103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 4 NC_051361.1 (12611352..12615154, complement)

    Chromosome 4 - NC_085110.1Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase lubel Neighboring gene uncharacterized LOC110386028 Neighboring gene CWC25 spliceosome associated protein homolog Neighboring gene uncharacterized LOC134198804 Neighboring gene uncharacterized LOC119628443 Neighboring gene small ribonucleoprotein particle protein SmB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 20E-mediated regulation of BmKr-h1 by BmKRP promotes oocyte maturation. Zhu Z, et al. BMC Biol, 2021 Feb 25. PMID 33632227, Free PMC Article
    2. Hormonal regulation and developmental role of Krüppel homolog 1, a repressor of metamorphosis, in the silkworm Bombyx mori. Kayukawa T, et al. Dev Biol, 2014 Apr 1. PMID 24508345
    3. 20-hydroxyecdysone and juvenile hormone analog prevent precocious metamorphosis in recessive trimolter mutants of Bombyx mori. Wang HB, et al. Insect Biochem Mol Biol, 2012 Feb. PMID 22155635
    4. Molecular mechanism underlying juvenile hormone-mediated repression of precocious larval-adult metamorphosis. Kayukawa T, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096379, Free PMC Article
    5. Krüppel Homolog 1 Inhibits Insect Metamorphosis via Direct Transcriptional Repression of Broad-Complex, a Pupal Specifier Gene. Kayukawa T, et al. J Biol Chem, 2016 Jan 22. PMID 26518872, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 20E-mediated regulation of BmKr-h1 by BmKRP promotes oocyte maturation.
      Title: 20E-mediated regulation of BmKr-h1 by BmKRP promotes oocyte maturation.
    2. Kr-h1 represses ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes in both Drosophila and Bombyx.
      Title: Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes.
    3. Kr-h1 directly binds to a consensus binding site in E93. A C-terminal conserved domain in Kr-h1 is essential for the transcriptional repression of E93. JH-inducible Kr-h1 directly binds to the KBS site upstream of the E93 locus to repress its transcription in a cell-autonomous manner, preventing larva from bypassing pupation.
      Title: Molecular mechanism underlying juvenile hormone-mediated repression of precocious larval-adult metamorphosis.
    4. In larvae, uvenile hormone induced the expression of Kr-h1 and concurrently suppressed 20-hydroxyecdysone-induced expression of BR-C.
      Title: Krüppel Homolog 1 Inhibits Insect Metamorphosis via Direct Transcriptional Repression of Broad-Complex, a Pupal Specifier Gene.
    5. Data indicate that the mutation of core base of transcription factor Kruppel (Kr) site suggesting that Kr functioned positively in rutin-mediated glutathione S-transferase delta 1 (BmGSTd1) transcription.
      Title: Activation of BmGSTd1 promoter and regulation by transcription factor Krüppel (Kr) in silkworm, Bombyx mori.
    6. Kr-h1 is indeed involved in the repression of metamorphosis but Kr-h1 alone is incapable of implementing normal larval molt
      Title: Hormonal regulation and developmental role of Krüppel homolog 1, a repressor of metamorphosis, in the silkworm Bombyx mori.
    7. Transcriptional regulation of juvenile hormone-mediated induction of Kruppel homolog 1, a repressor of insect metamorphosis.
      Title: Transcriptional regulation of juvenile hormone-mediated induction of Krüppel homolog 1, a repressor of insect metamorphosis.
    8. expression reflected larval-pupal transition of the recessive trimolter
      Title: 20-hydroxyecdysone and juvenile hormone analog prevent precocious metamorphosis in recessive trimolter mutants of Bombyx mori.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kruppel homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177861.1 → NP_001171332.1  Kruppel homolog 1

      See identical proteins and their annotated locations for NP_001171332.1

      Status: PROVISIONAL

      Source sequence(s)
      AB360766
      UniProtKB/TrEMBL
      D4Q9I0, G5ELN7
      Conserved Domains (2) summary
      COG5048
      Location:38 → 196
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:40 → 60
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM3026992v2 Primary Assembly

    Genomic

    1. NC_085110.1 Reference ASM3026992v2 Primary Assembly

      Range
      12831230..12840096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_062677075.1 → XP_062533059.1  Kruppel homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8R2R642

    2. XM_062677076.1 → XP_062533060.1  Kruppel homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8R2R642

    3. XM_038021714.2 → XP_037877642.1  Kruppel homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8R2R642, G5ELN7
      Conserved Domains (2) summary
      COG5048
      Location:38 → 196
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:40 → 60
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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