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    GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough [ Homo sapiens (human) ]

    Gene ID: 100527949, updated on 28-Oct-2024

    Summary

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    Official Symbol
    GIMAP1-GIMAP5provided by HGNC
    Official Full Name
    GIMAP1-GIMAP5 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:51257
    See related
    Ensembl:ENSG00000281887 AllianceGenome:HGNC:51257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This locus represents naturally occurring readthrough transcription between the neighboring GIMAP1 (GTPase, IMAP family member 1) and GIMAP5 (GTPase, IMAP family member 5) genes on chromosome 7. Alternative splicing results in multiple readthrough transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jan 2015]
    Expression
    Broad expression in lymph node (RPKM 55.4), spleen (RPKM 41.4) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GIMAP1-GIMAP5 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150716613..150743646)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151889523..151916554)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150413701..150440734)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901774 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26841 Neighboring gene GTPase, IMAP family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150403727-150404226 Neighboring gene GTPase, IMAP family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:150432641-150433627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26843 Neighboring gene GTPase, IMAP family member 5 Neighboring gene GTPase, IMAP family member 3 pseudogene Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36. Stamm O, et al. Gene, 2002 Jan 9. PMID 11814688
    2. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. Krücken J, et al. Gene, 2004 Oct 27. PMID 15474311
    3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
    4. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    GIMAP1-GIMAP5 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199577.2 → NP_001186506.1  GIMAP1-GIMAP5 protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC006479, FY213136
      UniProtKB/TrEMBL
      A0A087WTJ2
      Related
      ENSP00000477920.1, ENST00000611999.4
      Conserved Domains (2) summary
      cd01852
      Location:232 → 432
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
      pfam04548
      Location:28 → 135
      AIG1; AIG1 family

    2. NM_001303630.2 → NP_001290559.1  GIMAP1-GIMAP5 protein isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC006479, FY210894
      UniProtKB/TrEMBL
      B4DNE2
      Conserved Domains (1) summary
      cd01852
      Location:104 → 304
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      150716613..150743646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151889523..151916554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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