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    Atp7a ATPase copper transporting alpha [ Cricetulus griseus (Chinese hamster) ]

    Gene ID: 100689242, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Atp7a
    Gene description
    ATPase copper transporting alpha
    Locus tag
    I79_012483
    See related
    Ensembl:ENSCGRG00015017287
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cricetulus griseus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
    Orthologs
    human mouse all
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    Genomic context

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    See Atp7a in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614139.1 (590335..707176)
    104 current CriGri-PICRH-1.0 (GCF_003668045.3) X NC_048604.1 (64620954..64739191, complement)

    NW_003614139.1Genomic Context describing neighboring genes Neighboring gene magnesium transporter 1 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial Neighboring gene U6 spliceosomal RNA Neighboring gene toll-like receptor 13 Neighboring gene phosphoglycerate kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux. Camakaris J, et al. Hum Mol Genet, 1995 Nov. PMID 8589689
    2. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copper-transporting ATPase 1
    Names
    ATPase, Cu++ transporting, alpha polypeptide
    Copper pump 1
    Copper-transporting ATPase 1
    copper-binding ATPase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CriGri_1.0 Primary Assembly

    Genomic

    1. NW_003614139.1 Reference CriGri_1.0 Primary Assembly

      Range
      590335..707176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007645821.3 → XP_007644011.1  copper-transporting ATPase 1 isoform X1

      See identical proteins and their annotated locations for XP_007644011.1

      UniProtKB/TrEMBL
      A0A8C2LX90
      Conserved Domains (2) summary
      cd00371
      Location:380 → 442
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      cd02094
      Location:713 → 1379
      P-type_ATPase_Cu-like; P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B

    2. XM_035457690.1 → XP_035313581.1  copper-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C2LX90
      Conserved Domains (2) summary
      cd00371
      Location:380 → 442
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      cd02094
      Location:713 → 1379
      P-type_ATPase_Cu-like; P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B

    3. XM_027438585.1 → XP_027294386.1  copper-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C2LX90
      Conserved Domains (2) summary
      cd00371
      Location:380 → 442
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      cd02094
      Location:713 → 1379
      P-type_ATPase_Cu-like; P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B

    4. XM_016977069.3 → XP_016832558.1  copper-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C2LX90
      Conserved Domains (2) summary
      cd00371
      Location:380 → 442
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      cd02094
      Location:713 → 1379
      P-type_ATPase_Cu-like; P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B

    5. XM_035457691.1 → XP_035313582.1  copper-transporting ATPase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C2LX90
      Conserved Domains (2) summary
      cd00371
      Location:312 → 374
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      cd02094
      Location:645 → 1311
      P-type_ATPase_Cu-like; P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B

    Alternate CriGri-PICRH-1.0

    Genomic

    1. NC_048604.1 Alternate CriGri-PICRH-1.0

      Range
      64620954..64739191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027432881.2 → XP_027288682.1  copper-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C2LX90, A0A9J7JSW6

    2. XM_035449900.1 → XP_035305791.1  copper-transporting ATPase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C2LX90, A0A9J7H7E4
      Conserved Domains (2) summary
      cd00371
      Location:312 → 374
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
      cd02094
      Location:645 → 1311
      P-type_ATPase_Cu-like; P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B

    3. XM_027432878.2 → XP_027288679.1  copper-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C2LX90, A0A9J7JSW6

    4. XM_027432879.2 → XP_027288680.1  copper-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C2LX90, A0A9J7JSW6

    5. XM_027432880.2 → XP_027288681.1  copper-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C2LX90, A0A9J7JSW6
      Related
      ENSCGRP00015022898.1, ENSCGRT00015028095.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49015.1 GenPept UniProtKB/Swiss-Prot:P49015

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