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    pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Oreochromis niloticus (Nile tilapia) ]

    Gene ID: 100691647, updated on 8-Mar-2024

    Summary

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    Gene symbol
    pik3r1
    Gene description
    phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
    See related
    Ensembl:ENSONIG00000011065
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oreochromis niloticus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Oreochromini; Oreochromis
    Orthologs
    human zebrafish all
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    Genomic context

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    See pik3r1 in Genome Data Viewer
    Location:
    chromosome: LG7
    Exon count:
    17
    Annotation release Status Assembly LG Location
    104 current O_niloticus_UMD_NMBU (GCF_001858045.2) LG7 NC_031972.2 (13186290..13206819, complement)
    103 previous assembly ASM185804v2 (GCF_001858045.1) LG7 NC_031972.1 (2812541..2833327)

    Linkage Group LG7 - NC_031972.2Genomic Context describing neighboring genes Neighboring gene TNF receptor-associated factor 2 Neighboring gene tenascin Ca Neighboring gene uncharacterized LOC109202742 Neighboring gene uncharacterized LOC102077654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit alpha
    Names
    phosphoinositide-3-kinase regulatory subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Oreochromis niloticus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference O_niloticus_UMD_NMBU Primary Assembly

    Genomic

    1. NC_031972.2 Reference O_niloticus_UMD_NMBU Primary Assembly

      Range
      13186290..13206819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005454464.4 → XP_005454521.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_005454521.1

      UniProtKB/TrEMBL
      A0A669BMU2, A0A669ESG1
      Related
      ENSONIP00000074348.1, ENSONIT00000047008.1
      Conserved Domains (5) summary
      cd09930
      Location:622 → 725
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:328 → 438
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11910
      Location:5 → 79
      SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12924
      Location:443 → 603
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cd04388
      Location:117 → 305
      RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

    2. XM_005454466.4 → XP_005454523.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A669EZE2
      Conserved Domains (4) summary
      cd09930
      Location:355 → 458
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:61 → 171
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:176 → 336
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      pfam16454
      Location:175 → 334
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

    3. XM_005454467.4 → XP_005454524.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A669EZC8, A0A669EZE2
      Related
      ENSONIP00000078480.1, ENSONIT00000067205.1
      Conserved Domains (3) summary
      cd09930
      Location:298 → 401
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:4 → 114
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:119 → 279
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    Nucleotide Protein
    Heading Accession and Version

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