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    EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 [ Gorilla gorilla gorilla (western lowland gorilla) ]

    Gene ID: 101133221, updated on 3-Apr-2024

    Summary

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    Gene symbol
    EIF2AK2
    Gene description
    eukaryotic translation initiation factor 2 alpha kinase 2
    See related
    Ensembl:ENSGGOG00000005556
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gorilla gorilla gorilla (sub-species: gorilla)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Gorilla
    Orthologs
    human mouse all
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    Genomic context

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    See EIF2AK2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mGorGor1-v2.0_pri (GCF_029281585.2) 12 NC_073236.2 (102664069..102716788)
    RS_2023_04 previous assembly NHGRI_mGorGor1-v1.1-0.2.freeze_pri (GCF_029281585.1) 2A NC_073225.1 (43883946..43937690, complement)

    Chromosome 12 - NC_073236.2Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene sulfotransferase family 6B member 1 Neighboring gene ARL14 effector protein-like Neighboring gene G-patch domain containing 11 Neighboring gene HEAT repeat containing 5B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein kinase R reveals an evolutionary model for defeating viral mimicry. Elde NC, et al. Nature, 2009 Jan 22. PMID 19043403, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-induced, double-stranded RNA-activated protein kinase
    NP_001266614.1
    XP_018876138.3
    XP_063551512.1
    XP_063551513.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001279685.1 → NP_001266614.1  interferon-induced, double-stranded RNA-activated protein kinase

      See identical proteins and their annotated locations for NP_001266614.1

      Status: PROVISIONAL

      Source sequence(s)
      EU733258
      UniProtKB/TrEMBL
      B9UKH9, G3SCH4
      Related
      ENSGGOP00000025802.2, ENSGGOT00000024827.2
      Conserved Domains (3) summary
      smart00220
      Location:267 → 534
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00358
      Location:101 → 165
      DSRM; Double-stranded RNA binding motif
      cd14047
      Location:260 → 536
      STKc_EIF2AK2_PKR; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA

    RefSeqs of Annotated Genomes: GCF_029281585.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mGorGor1-v2.0_pri Primary Assembly

    Genomic

    1. NC_073236.2 Reference NHGRI_mGorGor1-v2.0_pri Primary Assembly

      Range
      102664069..102716788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063695442.1 → XP_063551512.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

      UniProtKB/TrEMBL
      G3RTN4

    2. XM_019020593.4 → XP_018876138.3  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

      UniProtKB/TrEMBL
      G3RTN4

    3. XM_063695443.1 → XP_063551513.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X2

    Nucleotide Protein
    Heading Accession and Version

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