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    Duox2 dual oxidase 2 [ Ictidomys tridecemlineatus (thirteen-lined ground squirrel) ]

    Gene ID: 101966476, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Duox2
    Gene description
    dual oxidase 2
    Locus tag
    H1C71_016707
    See related
    EnsemblRapid:ENSSTOG00015018659
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ictidomys tridecemlineatus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae; Xerinae; Marmotini; Ictidomys
    Orthologs
    human mouse all
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    Genomic context

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    See Duox2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    103 current HiC_Itri_2 (GCF_016881025.1) Unplaced Scaffold NW_024408640.1 (89964100..89983254, complement)
    102 previous assembly SpeTri2.0 (GCF_000236235.1) Unplaced Scaffold NW_004936471.1 (7812163..7831258, complement)

    NW_024408640.1Genomic Context describing neighboring genes Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene sorbitol dehydrogenase Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual oxidase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Ictidomys tridecemlineatus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HiC_Itri_2 Primary Assembly

    Genomic

    1. NW_024408640.1 Reference HiC_Itri_2 Primary Assembly

      Range
      89964100..89983254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021726516.2 → XP_021582191.2  dual oxidase 2 isoform X2

      UniProtKB/TrEMBL
      I3MC83
      Related
      ENSSTOP00015023112.1, ENSSTOT00015025195.1
      Conserved Domains (4) summary
      cd06186
      Location:1287 → 1560
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:53 → 609
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      PLN02292
      Location:1133 → 1416
      PLN02292; ferric-chelate reductase
      cd00051
      Location:839 → 900
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_040275158.1 → XP_040131092.1  dual oxidase 2 isoform X1

      UniProtKB/TrEMBL
      I3MC83
      Conserved Domains (4) summary
      cd06186
      Location:1315 → 1588
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:53 → 609
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      PLN02292
      Location:1161 → 1444
      PLN02292; ferric-chelate reductase
      cd00051
      Location:839 → 928
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version

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