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    EPRS1 glutamyl-prolyl-tRNA synthetase 1 [ Myotis lucifugus (little brown bat) ]

    Gene ID: 102435652, updated on 30-Mar-2024

    Summary

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    Gene symbol
    EPRS1
    Gene description
    glutamyl-prolyl-tRNA synthetase 1
    See related
    Ensembl:ENSMLUG00000007253
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Myotis lucifugus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Vespertilionidae; Myotis
    Also known as
    EPRS
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: Un
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    102 current Myoluc2.0 (GCF_000147115.1) Unplaced Scaffold NW_005871181.1 (161870..206505)

    NW_005871181.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene RAB3 GTPase activating non-catalytic protein subunit 2 Neighboring gene isoleucyl-tRNA synthetase 2, mitochondrial Neighboring gene U2 spliceosomal RNA Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene solute carrier family 30 member 10 Neighboring gene lysophospholipase like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_005871181 Unplaced Scaffold Reference Myoluc2.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables proline-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in prolyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: bifunctional glutamate/proline--tRNA ligase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Myotis lucifugus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Myoluc2.0

    Genomic

    1. NW_005871181.1 Reference Myoluc2.0

      Range
      161870..206505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006094327.3 → XP_006094389.2  LOW QUALITY PROTEIN: bifunctional glutamate/proline--tRNA ligase

      UniProtKB/TrEMBL
      G1P8Y2
      Related
      ENSMLUP00000006654.2, ENSMLUT00000007293.2
      Conserved Domains (9) summary
      cd10309
      Location:74 → 157
      GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
      PLN02907
      Location:13 → 686
      PLN02907; glutamate-tRNA ligase
      PRK08661
      Location:994 → 1487
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00778
      Location:998 → 1261
      ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00862
      Location:1267 → 1487
      ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
      cd00936
      Location:801 → 845
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      pfam00458
      Location:728 → 780
      WHEP-TRS; WHEP-TRS domain
      pfam03950
      Location:479 → 656
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
      cl00015
      Location:197 → 477
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version

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