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    POTEB3 POTE ankyrin domain family member B3 [ Homo sapiens (human) ]

    Gene ID: 102724631, updated on 10-Oct-2024

    Summary

    Official Symbol
    POTEB3provided by HGNC
    Official Full Name
    POTE ankyrin domain family member B3provided by HGNC
    Primary source
    HGNC:HGNC:51240
    See related
    Ensembl:ENSG00000278522 AllianceGenome:HGNC:51240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POTEB; POTE-15
    Expression
    Restricted expression toward testis (RPKM 3.9) See more
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    Genomic context

    See POTEB3 in Genome Data Viewer
    Location:
    15q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (21405401..21440499, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (18748387..18783424, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CXADR pseudogene 2 Neighboring gene GRAM domain containing 4 pseudogene 6 Neighboring gene microRNA 3118-3 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC105369227 Neighboring gene neurofibromin 1 pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of POTE ankyrin domain family, member B (POTEB) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC87614, MGC119371, MGC119372, MGC119373, MGC156116

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    POTE ankyrin domain family member B3
    Names
    ANKRD26-like family B member 1
    POTE ankyrin domain family member B
    POTE ankyrin domain family, member B-like
    prostate, ovary, testis-expressed protein on chromosome 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207355.5 → NP_997238.2  POTE ankyrin domain family member B3

      See identical proteins and their annotated locations for NP_997238.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
      Source sequence(s)
      AC060814
      Consensus CDS
      CCDS73690.1
      UniProtKB/Swiss-Prot
      A0A096LPD0, A0JP26, Q6NXN7, Q6S5H4, Q6S5H7
      UniProtKB/TrEMBL
      A0A087X187
      Related
      ENSP00000483103.1, ENST00000611217.5
      Conserved Domains (4) summary
      cd00204
      Location:167 → 292
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:177 → 269
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:143 → 193
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:174 → 203
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_110752.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons but includes alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC060814, BC066981, BC127123
      Related
      ENST00000612601.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      21405401..21440499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543797.3 → XP_011542099.1  POTE ankyrin domain family member B3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JQ08
      Conserved Domains (2) summary
      sd00045
      Location:174 → 203
      ANK; ANK repeat [structural motif]
      cl39094
      Location:158 → 361
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_047432107.1 → XP_047288063.1  POTE ankyrin domain family member B3 isoform X1

      UniProtKB/TrEMBL
      A0A0C4DH93
      Related
      ENSP00000485523.1, ENST00000624267.3
    3. XM_011543796.3 → XP_011542098.1  POTE ankyrin domain family member B3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JQ08
      Conserved Domains (2) summary
      sd00045
      Location:174 → 203
      ANK; ANK repeat [structural motif]
      cl39094
      Location:158 → 361
      Ank_2; Ankyrin repeats (3 copies)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      1961872..2029684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332571.1 → XP_054188546.1  POTE ankyrin domain family member B3 isoform X4

      UniProtKB/TrEMBL
      Q495V6
    2. XM_054332574.1 → XP_054188549.1  POTE ankyrin domain family member B3 isoform X3

    3. XM_054332572.1 → XP_054188547.1  POTE ankyrin domain family member B3 isoform X1

      UniProtKB/TrEMBL
      A0A0C4DH93
    4. XM_054332573.1 → XP_054188548.1  POTE ankyrin domain family member B3 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187602.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      163348..198439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329031.1 → XP_054185006.1  POTE ankyrin domain family member B3 isoform X3

    2. XM_054329029.1 → XP_054185004.1  POTE ankyrin domain family member B3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JQB7
    3. XM_054329030.1 → XP_054185005.1  POTE ankyrin domain family member B3 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      18748387..18783424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377203.1 → XP_054233178.1  POTE ankyrin domain family member B3 isoform X3

    2. XM_054377201.1 → XP_054233176.1  POTE ankyrin domain family member B3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JQB7
    3. XM_054377202.1 → XP_054233177.1  POTE ankyrin domain family member B3 isoform X2