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    OAZ3 ornithine decarboxylase antizyme 3 [ Chrysochloris asiatica (Cape golden mole) ]

    Gene ID: 102820242, updated on 10-Mar-2024

    Summary

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    Gene symbol
    OAZ3
    Gene description
    ornithine decarboxylase antizyme 3
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Chrysochloris asiatica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Chrysochloridae; Chrysochlorinae; Chrysochloris
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been noted for this gene. [provided by RefSeq, Aug 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See OAZ3 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    100 current ChrAsi1.0 (GCF_000296735.1) Unplaced Scaffold NW_006408560.1 (8861304..8867955)

    NW_006408560.1Genomic Context describing neighboring genes Neighboring gene CUGBP Elav-like family member 3 Neighboring gene regulatory subunit of type II PKA R-subunit domain containing 1 Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene tudor and KH domain containing Neighboring gene leucine rich repeat and Ig domain containing 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_006408560 unplaced scaffold reference ChrAsi1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polyamines in spermiogenesis: not now, darling. Coffino P. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781034, Free PMC Article
    2. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ornithine decarboxylase antizyme 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290657.1 → NP_001277586.1  ornithine decarboxylase antizyme 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (2) is shorter with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AMDV01102210
      UniProtKB/TrEMBL
      A0A9B0WNM0
      Conserved Domains (1) summary
      pfam02100
      Location:82 → 178
      ODC_AZ; Ornithine decarboxylase antizyme

    2. NM_001301633.1 → NP_001288562.1  ornithine decarboxylase antizyme 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) initiates translation from a non-AUG (CUG) start codon, and encodes the longer isoform (1).
      Source sequence(s)
      AMDV01102210
      Conserved Domains (1) summary
      pfam02100
      Location:127 → 223
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Chrysochloris asiatica Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ChrAsi1.0 Primary Assembly

    Genomic

    1. NW_006408560.1 Reference ChrAsi1.0 Primary Assembly

      Range
      8861304..8867955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006861435.1 → XP_006861497.1  ornithine decarboxylase antizyme 3

      Conserved Domains (1) summary
      pfam02100
      Location:82 → 178
      ODC_AZ; Ornithine decarboxylase antizyme
    Nucleotide Protein
    Heading Accession and Version

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