U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    OAZ2 ornithine decarboxylase antizyme 2 [ Chrysochloris asiatica (Cape golden mole) ]

    Gene ID: 102833047, updated on 10-Mar-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    OAZ2
    Gene description
    ornithine decarboxylase antizyme 2
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Chrysochloris asiatica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Chrysochloridae; Chrysochlorinae; Chrysochloris
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See OAZ2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    100 current ChrAsi1.0 (GCF_000296735.1) Unplaced Scaffold NW_006408522.1 (4354835..4367027)

    NW_006408522.1Genomic Context describing neighboring genes Neighboring gene hsc70-interacting protein-like Neighboring gene RNA binding protein, mRNA processing factor 2 Neighboring gene poly(rC) binding protein 2 pseudogene Neighboring gene zinc finger protein 609 Neighboring gene transmembrane emp24 protein transport domain containing 5 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NW_006408522 unplaced scaffold reference ChrAsi1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ornithine decarboxylase antizyme 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290197.1 → NP_001277126.1  ornithine decarboxylase antizyme 2

      Status: REVIEWED

      Source sequence(s)
      AMDV01014256, AMDV01014257
      UniProtKB/TrEMBL
      A0A9B0WE05
      Conserved Domains (1) summary
      pfam02100
      Location:98 → 181
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Chrysochloris asiatica Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ChrAsi1.0 Primary Assembly

    Genomic

    1. NW_006408522.1 Reference ChrAsi1.0 Primary Assembly

      Range
      4354835..4367027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006831539.1 → XP_006831602.1  ornithine decarboxylase antizyme 2

      Conserved Domains (1) summary
      pfam02100
      Location:98 → 181
      ODC_AZ; Ornithine decarboxylase antizyme
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.