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    GHR growth hormone receptor [ Physeter catodon (sperm whale) ]

    Gene ID: 102996314, updated on 10-Oct-2024

    Summary

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    Gene symbol
    GHR
    Gene description
    growth hormone receptor
    See related
    Ensembl:ENSPCTG00005019431
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Physeter catodon
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Physeteridae; Physeter
    Orthologs
    human mouse all
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    Genomic context

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    See GHR in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_04 current ASM283717v5 (GCF_002837175.3) 8 NC_041221.1 (51705002..51997066)
    102 previous assembly ASM283717v2 (GCF_002837175.2) 8 NC_041221.1 (51705002..51997043)

    Chromosome 8 - NC_041221.1Genomic Context describing neighboring genes Neighboring gene protein FAM136A-like Neighboring gene RAB7A interacting MON1-CCZ1 complex subunit 1 Neighboring gene F-box protein 4 Neighboring gene uncharacterized LOC114486708 Neighboring gene CCAAT/enhancer-binding protein gamma-like Neighboring gene coiled-coil domain containing 152

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of growth hormone receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth hormone receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002837175.3-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM283717v5 Primary Assembly

    Genomic

    1. NC_041221.1 Reference ASM283717v5 Primary Assembly

      Range
      51705002..51997066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007117758.4 → XP_007117820.1  growth hormone receptor isoform X2

      UniProtKB/TrEMBL
      A0A2Y9F9G9, A0A3Q8BRF4
      Related
      ENSPCTP00005027243.1, ENSPCTT00005029998.1
      Conserved Domains (3) summary
      cd00063
      Location:149 → 250
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:316 → 619
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49 → 127
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_028492885.2 → XP_028348686.1  growth hormone receptor isoform X2

      UniProtKB/TrEMBL
      A0A2Y9F9G9, A0A3Q8BRF4
      Conserved Domains (3) summary
      cd00063
      Location:149 → 250
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:316 → 619
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49 → 127
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_028492886.2 → XP_028348687.1  growth hormone receptor isoform X2

      UniProtKB/TrEMBL
      A0A2Y9F9G9, A0A3Q8BRF4
      Conserved Domains (3) summary
      cd00063
      Location:149 → 250
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:316 → 619
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49 → 127
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_055086536.1 → XP_054942511.1  growth hormone receptor isoform X2

      UniProtKB/TrEMBL
      A0A2Y9F9G9

    5. XM_055086537.1 → XP_054942512.1  growth hormone receptor isoform X2

      UniProtKB/TrEMBL
      A0A2Y9F9G9
      Related
      ENSPCTP00005027308.1, ENSPCTT00005030064.1

    6. XM_028492884.2 → XP_028348685.1  growth hormone receptor isoform X1

      UniProtKB/TrEMBL
      A0A3Q8BRF4, A0A455BI91
      Conserved Domains (3) summary
      cd00063
      Location:175 → 276
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:342 → 645
      GHBP; Growth hormone receptor binding
      cl21522
      Location:75 → 153
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein
    Heading Accession and Version

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