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    NFKB2 nuclear factor kappa B subunit 2 [ Parus major (Great Tit) ]

    Gene ID: 107206811, updated on 3-Aug-2024

    Summary

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    Gene symbol
    NFKB2
    Gene description
    nuclear factor kappa B subunit 2
    See related
    Ensembl:ENSPMJG00000015521
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Parus major
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves; Passeriformes; Paridae; Parus
    Orthologs
    human mouse all
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    Genomic context

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    See NFKB2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    102 current Parus_major1.1 (GCF_001522545.3) 6 NC_031775.1 (12324873..12335606)
    100 previous assembly Parus_major1.0.3 (GCF_001522545.1) 6 NC_029275.1 (11318808..11329509)

    Chromosome 6 - NC_031775.1Genomic Context describing neighboring genes Neighboring gene golgi brefeldin A resistant guanine nucleotide exchange factor 1 Neighboring gene transmembrane protein 150A Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene F-box and leucine rich repeat protein 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor NF-kappa-B p100 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Parus major Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Parus_major1.1 Primary Assembly

    Genomic

    1. NC_031775.1 Reference Parus_major1.1 Primary Assembly

      Range
      12324873..12335606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015633062.3 → XP_015488548.1  nuclear factor NF-kappa-B p100 subunit isoform X2

      Conserved Domains (5) summary
      cd07934
      Location:60 → 243
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      PHA03095
      Location:471 → 706
      PHA03095; ankyrin-like protein; Provisional
      cd01177
      Location:250 → 349
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      sd00045
      Location:609 → 640
      ANK; ANK repeat [structural motif]
      cl14633
      Location:810 → 885
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_015633063.3 → XP_015488549.1  nuclear factor NF-kappa-B p100 subunit isoform X3

      Related
      ENSPMJP00000020898.1, ENSPMJT00000027190.1
      Conserved Domains (7) summary
      cd07934
      Location:45 → 228
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      cd00204
      Location:518 → 683
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:235 → 334
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:600 → 693
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:485 → 544
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:594 → 625
      ANK; ANK repeat [structural motif]
      cl14633
      Location:795 → 870
      DD; Death Domain Superfamily of protein-protein interaction domains

    3. XM_033515847.1 → XP_033371738.1  nuclear factor NF-kappa-B p100 subunit isoform X2

      Related
      ENSPMJP00000020897.1, ENSPMJT00000027189.1
      Conserved Domains (5) summary
      cd07934
      Location:60 → 243
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      PHA03095
      Location:471 → 706
      PHA03095; ankyrin-like protein; Provisional
      cd01177
      Location:250 → 349
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      sd00045
      Location:609 → 640
      ANK; ANK repeat [structural motif]
      cl14633
      Location:810 → 885
      DD; Death Domain Superfamily of protein-protein interaction domains

    4. XM_015633060.3 → XP_015488546.1  nuclear factor NF-kappa-B p100 subunit isoform X1

      Conserved Domains (7) summary
      cd07934
      Location:67 → 250
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      cd00204
      Location:540 → 705
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:257 → 356
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:622 → 715
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:507 → 566
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:616 → 647
      ANK; ANK repeat [structural motif]
      cl14633
      Location:817 → 892
      DD; Death Domain Superfamily of protein-protein interaction domains
    Nucleotide Protein
    Heading Accession and Version

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