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    JAK1 Janus kinase 1 [ Manis javanica (Malayan pangolin) ]

    Gene ID: 108405993, updated on 11-Apr-2024

    Summary

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    Gene symbol
    JAK1
    Gene description
    Janus kinase 1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Manis javanica
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis
    Orthologs
    human mouse all
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    Genomic context

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    See JAK1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    101 current YNU_ManJav_2.0 (GCF_014570535.1) Unplaced Scaffold NW_023436097.1 (4528232..4663660, complement)
    100 previous assembly ManJav1.0 (GCF_001685135.1) Unplaced Scaffold NW_016541333.1 (13287..64535, complement)

    NW_023436097.1Genomic Context describing neighboring genes Neighboring gene VWFA and cache domain-containing protein 1-like Neighboring gene VWFA and cache domain-containing protein 1 Neighboring gene ribonucleoprotein, PTB binding 2 Neighboring gene NADH-cytochrome b5 reductase 3-like Neighboring gene eukaryotic translation initiation factor 4E type 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase JAK1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Manis javanica Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference YNU_ManJav_2.0 Primary Assembly

    Genomic

    1. NW_023436097.1 Reference YNU_ManJav_2.0 Primary Assembly

      Range
      4528232..4663660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_037024378.1 → XP_036880273.1  tyrosine-protein kinase JAK1

      Conserved Domains (6) summary
      cd05079
      Location:869 → 1152
      PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd05077
      Location:582 → 845
      PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
      cd13332
      Location:282 → 426
      FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
      pfam18377
      Location:147 → 277
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:36 → 129
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:426 → 526
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version

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