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    Glo1 glyoxalase 1 [ Mus musculus (house mouse) ]

    Gene ID: 109801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Glo1provided by MGI
    Official Full Name
    glyoxalase 1provided by MGI
    Primary source
    MGI:MGI:95742
    See related
    Ensembl:ENSMUSG00000024026 AllianceGenome:MGI:95742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLY1; Qglo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; 0610009E22Rik; 1110008E19Rik; 2510049H23Rik
    Summary
    Enables lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 62.5), liver E18 (RPKM 45.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Glo1 in Genome Data Viewer
    Location:
    17 A3.3; 17 15.69 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (30811835..30831633, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (30592861..30612659, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 9 Neighboring gene predicted gene, 25049 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene VISTA enhancer mm1326 Neighboring gene STARR-positive B cell enhancer ABC_E2480 Neighboring gene STARR-positive B cell enhancer ABC_E8666 Neighboring gene RIKEN cDNA 1700097N02 gene Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene dynein, axonemal, heavy chain 8 Neighboring gene predicted gene, 24661

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assignment of the gene for glyoxylase I to mouse chromosome 17 by somatic cell genetics. Leinwand L, et al. Biochem Genet, 1978 Aug. PMID 569476
    2. Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors. Hollenbach M, et al. Biochem Pharmacol, 2008 Sep 1. PMID 18625205
    3. Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor. Zhang H, et al. Acta Pharmacol Sin, 2015 Sep. PMID 26279158, Free PMC Article
    4. Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice. McMurray KM, et al. Addict Biol, 2017 Mar. PMID 26691867, Free PMC Article
    5. A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice. Wortmann M, et al. J Diabetes Res, 2016. PMID 26788517, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpressing glyoxalase 1 attenuates acute hyperglycemia-exacerbated neurological deficits of ischemic stroke in mice.
      Title: Overexpressing glyoxalase 1 attenuates acute hyperglycemia-exacerbated neurological deficits of ischemic stroke in mice.
    2. Glyoxalase 1 knockdown induces age-related beta-cell dysfunction and glucose intolerance in mice.
      Title: Glyoxalase 1 knockdown induces age-related β-cell dysfunction and glucose intolerance in mice.
    3. Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.
      Title: Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.
    4. Phosphorylation of T107 by CamKIIdelta Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.
      Title: Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.
    5. RAGE-independent up-regulation of Glo1 in RAGE-KO mice might be as another explanation for, at least some, effects attributed to RAGE before.
      Title: Gene doubling increases glyoxalase 1 expression in RAGE knockout mice.
    6. The protein expression of GLO1 in basilar arteries from hypertensive mice was decreased, and GLO1 expression was negatively correlated with medial cross-sectional area and blood pressure in basilar arteries during hypertension.
      Title: Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular remodeling via promoting the proliferation of basilar smooth muscle cells in hypertension.
    7. Data suggest that GLO1 rescues bone marrow-derived progenitor cell dysfunction and facilitates wound healing in diabetic animals, at least partly through preventing methylglyoxal-induced impairment of IRE1alpha expression and activity.
      Title: Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
    8. The objective of the present study was to detect whether overexpression of methylglyoxal-metabolizing enzyme glyoxalase-1 (GLO1), which reduces reactive oxygen species in Diabetic Adipose-Derived Stem Cells, can restore their proangiogenic function in a streptozotocin-induced diabetic mice model of critical limb ischemia.
      Title: Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia.
    9. Transgenic mice overexpressing Glo1 on both FVB/NJ (FVB) or C57BL/6J (B6) backgrounds showed increased voluntary EtOH consumption compared to their wild-type littermates. Transgenic Glo1 knockdown mice on a B6 background showed decreased voluntary EtOH consumption. Genetic manipulations of Glo1 had no effect on sucrose, saccharin or water consumption.
      Title: Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice.
    10. the Glo1-methylglyoxal pathway integrates maternal and neural precursor cell metabolism to regulate neural development.
      Title: A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lactoylglutathione lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lactoylglutathione lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lactoylglutathione lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in methylglyoxal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lactoylglutathione lyase
    Names
    S-D-lactoylglutathione methylglyoxal lyase
    aldoketomutase
    glx I
    glyoxalase 1 complex
    glyoxalase 1 regulatory
    glyoxalase 1 structural
    glyoxalase I
    ketone-aldehyde mutase
    methylglyoxalase
    NP_001107032.1
    NP_079650.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113560.1 → NP_001107032.1  lactoylglutathione lyase

      See identical proteins and their annotated locations for NP_001107032.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK049703, BG077218, BP769280, BY312309
      Consensus CDS
      CCDS28600.1
      UniProtKB/Swiss-Prot
      Q543L3, Q8R3T1, Q9CPU0
      UniProtKB/TrEMBL
      A5GZX3
      Related
      ENSMUSP00000126586.2, ENSMUST00000167624.2
      Conserved Domains (1) summary
      PLN03042
      Location:20 → 184
      PLN03042; Lactoylglutathione lyase; Provisional

    2. NM_025374.3 → NP_079650.3  lactoylglutathione lyase

      See identical proteins and their annotated locations for NP_079650.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK049703, BP769280, BY312309
      Consensus CDS
      CCDS28600.1
      UniProtKB/Swiss-Prot
      Q543L3, Q8R3T1, Q9CPU0
      UniProtKB/TrEMBL
      A5GZX3
      Related
      ENSMUSP00000158296.2, ENSMUST00000236335.2
      Conserved Domains (1) summary
      PLN03042
      Location:20 → 184
      PLN03042; Lactoylglutathione lyase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      30811835..30831633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPU0.3 GenPept UniProtKB/Swiss-Prot:Q9CPU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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