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    CMTM7 CKLF like MARVEL transmembrane domain containing 7 [ Homo sapiens (human) ]

    Gene ID: 112616, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CMTM7provided by HGNC
    Official Full Name
    CKLF like MARVEL transmembrane domain containing 7provided by HGNC
    Primary source
    HGNC:HGNC:19178
    See related
    Ensembl:ENSG00000153551 MIM:607890; AllianceGenome:HGNC:19178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKLFSF7
    Summary
    This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in lymph node (RPKM 7.5), spleen (RPKM 7.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CMTM7 in Genome Data Viewer
    Location:
    3p22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (32391853..32455528)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (32388830..32452466)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32433345..32497020)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CKLF like MARVEL transmembrane domain containing 8 Neighboring gene keratin 18 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19633 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:32400389-32401068 Neighboring gene uncharacterized LOC124909361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32442473-32443342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32443343-32444210 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:32448051-32448552 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:32461132-32462331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32478107-32478788 Neighboring gene Sharpr-MPRA regulatory region 14110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:32495222-32495722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19637 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:32501507-32502217 Neighboring gene Sharpr-MPRA regulatory region 13101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14174 Neighboring gene CKLF like MARVEL transmembrane domain containing 6 Neighboring gene microRNA 548ay

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CMTM7 inhibits breast cancer progression by regulating Wnt/β-catenin signaling. Chen ZH, et al. Breast Cancer Res, 2023 Feb 24. PMID 36829181, Free PMC Article
    2. Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children. Zhu Q, et al. Int J Environ Res Public Health, 2020 Feb 26. PMID 32111069, Free PMC Article
    3. Overexpression of CMTM7 inhibits cell growth and migration in liver cancer. Huang ZM, et al. Kaohsiung J Med Sci, 2019 Jun. PMID 30903681
    4. Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer. Liu Q, et al. Chin Med J (Engl), 2013 Aug. PMID 23981602
    5. A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth. Li H, et al. Oncogene, 2014 Jun 12. PMID 23893243

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CMTM7 inhibits breast cancer progression by regulating Wnt/beta-catenin signaling.
      Title: CMTM7 inhibits breast cancer progression by regulating Wnt/β-catenin signaling.
    2. CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity.
      Title: CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity.
    3. Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis.
      Title: Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis.
    4. CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.
      Title: CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.
    5. Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children.
      Title: Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children.
    6. CMTM7 functions as a tumor suppressor in liver cancer through suppression of cell cycle progression.
      Title: Overexpression of CMTM7 inhibits cell growth and migration in liver cancer.
    7. SOX10 can regulate the proliferation and tumor formation of gastric cancer by regulating the expression of CMTM7.
      Title: SOX10-dependent CMTM7 expression inhibits cell proliferation and tumor growth in gastric carcinoma.
    8. Findings indicate the role of CMTM7 protein in the regulation of epidermal growth factor receptor (EGFR)-AKT proto-oncogene protein signaling in tumor cells, and as a molecule related to Rab5 GTP-binding protein activation.
      Title: CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation.
    9. Loss of CMTM7 by promoter CpG methylation is associated with neoplasms.
      Title: A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth.
    10. The CMTM7 expression may be related to survival of patients with non-smallcell lung cancer and a unique prognostic factor. CMTM7 may play an important role in NSCLC development.
      Title: Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30992

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B-1a B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 7
    Names
    chemokine-like factor super family 7
    chemokine-like factor superfamily 7
    chemokine-like factor superfamily member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138410.4 → NP_612419.1  CKLF-like MARVEL transmembrane domain-containing protein 7 isoform a

      See identical proteins and their annotated locations for NP_612419.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC098475, AF479263, CD366110
      Consensus CDS
      CCDS33730.1
      UniProtKB/Swiss-Prot
      Q5VLK1, Q96FZ5
      Related
      ENSP00000335605.5, ENST00000334983.10
      Conserved Domains (1) summary
      pfam01284
      Location:40 → 160
      MARVEL; Membrane-associating domain

    2. NM_181472.3 → NP_852137.1  CKLF-like MARVEL transmembrane domain-containing protein 7 isoform b

      See identical proteins and their annotated locations for NP_852137.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AF479263, AK308878
      Consensus CDS
      CCDS33731.1
      UniProtKB/Swiss-Prot
      Q96FZ5
      Related
      ENSP00000283621.5, ENST00000349718.8
      Conserved Domains (1) summary
      pfam01284
      Location:40 → 122
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      32391853..32455528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      32388830..32452466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345104.1 → XP_054201079.1  CKLF-like MARVEL transmembrane domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      F8WDZ3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96FZ5.1 GenPept UniProtKB/Swiss-Prot:Q96FZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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