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    Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 [ Mus musculus (house mouse) ]

    Gene ID: 11670, updated on 28-Oct-2024

    Summary

    Official Symbol
    Aldh3a1provided by MGI
    Official Full Name
    aldehyde dehydrogenase family 3, subfamily A1provided by MGI
    Primary source
    MGI:MGI:1353451
    See related
    Ensembl:ENSMUSG00000019102 AllianceGenome:MGI:1353451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ahd4; Aldh; Ahd-4; Aldh3
    Summary
    Enables 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytoplasm and membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; gonad; and liver. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in bladder adult (RPKM 55.3), stomach adult (RPKM 53.6) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Aldh3a1 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61099336..61109244)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61208510..61218418)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42080 Neighboring gene ribosomal protein S13, pseudogene 5 Neighboring gene aldehyde dehydrogenase family 3, subfamily A2 Neighboring gene STARR-positive B cell enhancer ABC_E6993 Neighboring gene STARR-seq mESC enhancer starr_29673 Neighboring gene STARR-seq mESC enhancer starr_29674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61123776-61123977 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular aldehyde metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cellular aldehyde metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aldehyde dehydrogenase, dimeric NADP-preferring
    Names
    alcohol dehydrogenase family 3, subfamily A1
    aldehyde dehydrogenase 3, stomach cytosolic (class 3)
    aldehyde dehydrogenase 4
    aldehyde dehydrogenase family 3 member A1
    dioxin-inducible aldehyde dehydrogenase 3
    NP_001106196.1
    NP_001318041.1
    NP_031462.2
    XP_006532086.1
    XP_006532087.1
    XP_006532089.1
    XP_006532090.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112725.1NP_001106196.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

      See identical proteins and their annotated locations for NP_001106196.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The encoded isoform (1) is shorter than isoform 2. Both variants 1 and 2 encode the same isoform (2).
      Source sequence(s)
      AK144241, EL957097, EL959139, EL959277, EL961165, EL963960
      Consensus CDS
      CCDS24808.1
      UniProtKB/Swiss-Prot
      B1ATI7, P47739, Q9R203
      UniProtKB/TrEMBL
      Q3UNF5
      Related
      ENSMUSP00000104356.2, ENSMUST00000108716.8
      Conserved Domains (1) summary
      cd07132
      Location:5447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    2. NM_001331112.1NP_001318041.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).
      Source sequence(s)
      AL646093, CX734286
      UniProtKB/TrEMBL
      B7ZN13
      Conserved Domains (1) summary
      cd07132
      Location:5447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    3. NM_007436.2NP_031462.2  aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

      See identical proteins and their annotated locations for NP_031462.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The encoded isoform (1) is shorter than isoform 2. Both variants 1 and 2 encode the same isoform (2).
      Source sequence(s)
      AK144241, AL646093, EL957097, EL959139, EL959277, EL961165, EL963960
      Consensus CDS
      CCDS24808.1
      UniProtKB/Swiss-Prot
      B1ATI7, P47739, Q9R203
      UniProtKB/TrEMBL
      Q3UNF5
      Related
      ENSMUSP00000019246.4, ENSMUST00000019246.4
      Conserved Domains (1) summary
      cd07132
      Location:5447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61099336..61109244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532024.3XP_006532087.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1

      See identical proteins and their annotated locations for XP_006532087.1

      UniProtKB/TrEMBL
      B7ZN13
      Conserved Domains (1) summary
      cd07132
      Location:5447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    2. XM_006532027.4XP_006532090.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X2

      See identical proteins and their annotated locations for XP_006532090.1

      UniProtKB/Swiss-Prot
      B1ATI7, P47739, Q9R203
      UniProtKB/TrEMBL
      Q3UNF5
      Conserved Domains (1) summary
      cd07132
      Location:5447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    3. XM_006532023.1XP_006532086.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1

      See identical proteins and their annotated locations for XP_006532086.1

      UniProtKB/TrEMBL
      B7ZN13
      Conserved Domains (1) summary
      cd07132
      Location:5447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    4. XM_006532026.1XP_006532089.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X2

      See identical proteins and their annotated locations for XP_006532089.1

      UniProtKB/Swiss-Prot
      B1ATI7, P47739, Q9R203
      UniProtKB/TrEMBL
      Q3UNF5
      Conserved Domains (1) summary
      cd07132
      Location:5447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins