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    PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [ Molossus molossus (Pallas's mastiff bat) ]

    Gene ID: 118642883, updated on 30-Mar-2024

    Summary

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    Gene symbol
    PIK3R1
    Gene description
    phosphoinositide-3-kinase regulatory subunit 1
    Locus tag
    HJG59_014244
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Molossus molossus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Molossidae; Molossus
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3R1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    100 current mMolMol1.p (GCF_014108415.1) Unplaced Scaffold NW_023425366.1 (46088283..46173274)

    NW_023425366.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-like Neighboring gene low molecular weight phosphotyrosine protein phosphatase-like Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC118642210 Neighboring gene uncharacterized LOC118642211

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_023425366 Unplaced Scaffold Reference mMolMol1.p

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Molossus molossus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mMolMol1.p

    Genomic

    1. NW_023425366.1 Reference mMolMol1.p

      Range
      46088283..46173274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036280914.1 → XP_036136807.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X5

      Conserved Domains (5) summary
      cd09930
      Location:658 → 761
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:366 → 476
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11910
      Location:5 → 79
      SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12924
      Location:481 → 641
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cd04388
      Location:155 → 343
      RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

    2. XM_036280907.1 → XP_036136800.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A7J8J2E3
      Conserved Domains (5) summary
      cd09930
      Location:617 → 720
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:325 → 435
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11910
      Location:5 → 79
      SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12924
      Location:440 → 600
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cd04388
      Location:114 → 302
      RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

    3. XM_036280910.1 → XP_036136803.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A7J8J2G5
      Conserved Domains (4) summary
      cd09930
      Location:412 → 515
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:120 → 230
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:235 → 395
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cl02570
      Location:1 → 97
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    4. XM_036280908.1 → XP_036136801.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A7J8J2E3
      Conserved Domains (5) summary
      cd09930
      Location:617 → 720
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:325 → 435
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11910
      Location:5 → 79
      SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12924
      Location:440 → 600
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cd04388
      Location:114 → 302
      RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

    5. XM_036280911.1 → XP_036136804.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A7J8J2G5
      Conserved Domains (4) summary
      cd09930
      Location:412 → 515
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:120 → 230
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:235 → 395
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
      cl02570
      Location:1 → 97
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    6. XM_036280913.1 → XP_036136806.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4

      UniProtKB/TrEMBL
      A0A7J8J158
      Conserved Domains (3) summary
      cd09930
      Location:317 → 420
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:25 → 135
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:140 → 300
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

    7. XM_036280912.1 → XP_036136805.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A7J8J2P1
      Conserved Domains (3) summary
      cd09930
      Location:347 → 450
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:55 → 165
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd12924
      Location:170 → 330
      iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    Nucleotide Protein
    Heading Accession and Version

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