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    KDM2B lysine demethylase 2B [ Choloepus didactylus (southern two-toed sloth) ]

    Gene ID: 119519110, updated on 21-Mar-2024

    Summary

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    Gene symbol
    KDM2B
    Gene description
    lysine demethylase 2B
    See related
    EnsemblRapid:ENSCDIG00005020374
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Choloepus didactylus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Xenarthra; Pilosa; Folivora; Megalonychidae; Choloepus
    Orthologs
    human mouse all
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    Genomic context

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    See KDM2B in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    100 current mChoDid1.pri (GCF_015220235.1) 23 NC_051329.1 (9506277..9627170)

    Chromosome 23 - NC_051329.1Genomic Context describing neighboring genes Neighboring gene MORN repeat containing 3 Neighboring gene uncharacterized LOC119519113 Neighboring gene ORAI calcium release-activated calcium modulator 1 Neighboring gene U6 spliceosomal RNA Neighboring gene ring finger protein 34 Neighboring gene anaphase promoting complex subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_051329.1 Chromosome 23 Reference mChoDid1.pri Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein demethylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine-specific demethylase 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Choloepus didactylus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mChoDid1.pri Primary Assembly

    Genomic

    1. NC_051329.1 Reference mChoDid1.pri Primary Assembly

      Range
      9506277..9627170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_037816542.1 → XP_037672470.1  lysine-specific demethylase 2B isoform X4

      Conserved Domains (9) summary
      cd09293
      Location:1088 → 1277
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1072 → 1096
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:628 → 689
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:582 → 618
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1038 → 1076
      F-box-like
      pfam17811
      Location:303 → 338
      JHD; Jumonji helical domain
      cd21785
      Location:474 → 540
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:198 → 304
      cupin_RmlC-like; RmlC-like cupin superfamily

    2. XM_037816543.1 → XP_037672471.1  lysine-specific demethylase 2B isoform X5

      Conserved Domains (9) summary
      cd09293
      Location:1085 → 1274
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:151 → 226
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1069 → 1093
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:628 → 689
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:582 → 618
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1035 → 1073
      F-box-like
      pfam17811
      Location:303 → 338
      JHD; Jumonji helical domain
      cd21785
      Location:474 → 540
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:198 → 304
      cupin_RmlC-like; RmlC-like cupin superfamily

    3. XM_037816544.1 → XP_037672472.1  lysine-specific demethylase 2B isoform X6

      Conserved Domains (9) summary
      cd09293
      Location:1082 → 1271
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:145 → 220
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1066 → 1090
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:622 → 683
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:576 → 612
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1032 → 1070
      F-box-like
      pfam17811
      Location:297 → 332
      JHD; Jumonji helical domain
      cd21785
      Location:468 → 534
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:192 → 298
      cupin_RmlC-like; RmlC-like cupin superfamily

    4. XM_037816539.1 → XP_037672467.1  lysine-specific demethylase 2B isoform X1

      Conserved Domains (9) summary
      cd09293
      Location:1231 → 1420
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:294 → 369
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1215 → 1239
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:771 → 832
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:725 → 761
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1181 → 1219
      F-box-like
      pfam17811
      Location:446 → 481
      JHD; Jumonji helical domain
      cd21785
      Location:617 → 683
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:341 → 447
      cupin_RmlC-like; RmlC-like cupin superfamily

    5. XM_037816540.1 → XP_037672468.1  lysine-specific demethylase 2B isoform X2

      Related
      ENSCDIP00005029028.1, ENSCDIT00005032789.1
      Conserved Domains (9) summary
      cd09293
      Location:1228 → 1417
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:294 → 369
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1212 → 1236
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:771 → 832
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:725 → 761
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1178 → 1216
      F-box-like
      pfam17811
      Location:446 → 481
      JHD; Jumonji helical domain
      cd21785
      Location:617 → 683
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:341 → 447
      cupin_RmlC-like; RmlC-like cupin superfamily

    6. XM_037816541.1 → XP_037672469.1  lysine-specific demethylase 2B isoform X3

      Conserved Domains (9) summary
      cd09293
      Location:1228 → 1417
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:291 → 366
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1212 → 1236
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:768 → 829
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:722 → 758
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1178 → 1216
      F-box-like
      pfam17811
      Location:443 → 478
      JHD; Jumonji helical domain
      cd21785
      Location:614 → 680
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:338 → 444
      cupin_RmlC-like; RmlC-like cupin superfamily

    7. XM_037816545.1 → XP_037672473.1  lysine-specific demethylase 2B isoform X7

      Related
      ENSCDIP00005029287.1, ENSCDIT00005033075.1
      Conserved Domains (9) summary
      cd09293
      Location:1079 → 1268
      AMN1; Antagonist of mitotic exit network protein 1
      smart00558
      Location:145 → 220
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00034
      Location:1063 → 1087
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:622 → 683
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:576 → 612
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:1029 → 1067
      F-box-like
      pfam17811
      Location:297 → 332
      JHD; Jumonji helical domain
      cd21785
      Location:468 → 534
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:192 → 298
      cupin_RmlC-like; RmlC-like cupin superfamily

    8. XM_037816546.1 → XP_037672474.1  lysine-specific demethylase 2B isoform X8

      Conserved Domains (8) summary
      cd09293
      Location:951 → 1140
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:935 → 959
      LRR_AMN1; leucine-rich repeat [structural motif]
      cd15644
      Location:491 → 552
      PHD_KDM2B; PHD finger found in Lysine-specific demethylase 2B (KDM2B)
      pfam02008
      Location:445 → 481
      zf-CXXC; CXXC zinc finger domain
      pfam12937
      Location:901 → 939
      F-box-like
      pfam17811
      Location:166 → 201
      JHD; Jumonji helical domain
      cd21785
      Location:337 → 403
      CTD_KDM2B; C-terminal domain found in Lysine-specific demethylase 2B
      cl40423
      Location:61 → 167
      cupin_RmlC-like; RmlC-like cupin superfamily

    RNA

    1. XR_005213949.1 RNA Sequence

      Related
      ENSCDIT00005033038.1
    Nucleotide Protein
    Heading Accession and Version

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