Bdnf brain derived neurotrophic factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bdnfprovided by MGI
Official Full Name: brain derived neurotrophic factorprovided by MGI
Primary source: MGI:MGI:88145
See related: Ensembl:ENSMUSG00000048482 AllianceGenome:MGI:88145
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Expression: Biased expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 56.63 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (109505045..109557388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (109674700..109727043)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
Title: Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis.
Title: Muscle-resident mesenchymal progenitors sense and repair peripheral nerve injury via the GDNF-BDNF axis.
miR-206-3p Targets Brain-Derived Neurotrophic Factor and Affects Postoperative Cognitive Function in Aged Mice.
Title: miR-206-3p Targets Brain-Derived Neurotrophic Factor and Affects Postoperative Cognitive Function in Aged Mice.
Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior.
Title: Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior.
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans.
Title: An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans.
Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways.
Title: Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways.
Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling.
Title: Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling.
Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure.
Title: Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure.
Glucose may Contribute to Retrieval and Reconsolidation of Contextual Fear Memory Through Hippocampal Nr4a3 and Bdnf mRNA Expression and May Act Synergically with Adrenaline.
Title: Glucose may Contribute to Retrieval and Reconsolidation of Contextual Fear Memory Through Hippocampal Nr4a3 and Bdnf mRNA Expression and May Act Synergically with Adrenaline.
TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level.
Title: TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level.

Submit: New GeneRIF Correction See all GeneRIFs (806)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (34) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BDNF (e-PCR)
- UniSTS:266531

UniSTS:463961 (e-PCR)
- UniSTS:463961

Bdnf (e-PCR), detects polymorphism
- UniSTS:463961

Bdnf (e-PCR), detects polymorphism
- UniSTS:256883

Bdnf (e-PCR), detects polymorphism
- UniSTS:506750

Bdnf (e-PCR), detects polymorphism
- UniSTS:530821

BE101548 (e-PCR)
- UniSTS:243609

Bdnf (e-PCR), detects polymorphism
- UniSTS:265642

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin TRKB receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to acid chemical	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in conditioned place preference	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite extension	IDA Inferred from Direct Assay more info	PubMed
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glutamate secretion	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mechanoreceptor differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron recognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of collateral sprouting	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glucocorticoid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regeneration	ISO Inferred from Sequence Orthology more info
involved_in regulation of axon extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of collateral sprouting	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of retinal cell programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of short-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within taste bud development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ureteric bud development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial crista	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: brain-derived neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048139.1 → NP_001041604.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001041604.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477, AY057911

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000106680.4, ENSMUST00000111051.10

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001048141.1 → NP_001041606.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001041606.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477, AY057913

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000106679.4, ENSMUST00000111050.10

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001048142.1 → NP_001041607.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001041607.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477, AY057914

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000106674.3, ENSMUST00000111045.9

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001285416.1 → NP_001272345.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001272345.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477, AY057910

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000106676.3, ENSMUST00000111047.9

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001285417.1 → NP_001272346.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001272346.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477, AY231131

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000106672.3, ENSMUST00000111043.9

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001285418.1 → NP_001272347.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001272347.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477, AY057909

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000106678.3, ENSMUST00000111049.9

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001285419.1 → NP_001272348.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001272348.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477, AY057912

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000106675.3, ENSMUST00000111046.9

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001285420.1 → NP_001272349.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001272349.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000135762.2, ENSMUST00000176893.8

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001285421.1 → NP_001272350.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001272350.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001285422.1 → NP_001272351.1 brain-derived neurotrophic factor isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001272351.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001316310.1 → NP_001303239.1 brain-derived neurotrophic factor isoform 2 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (12) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.

Source sequence(s)

AL732477, AY231132

Consensus CDS

CCDS38194.1

UniProtKB/Swiss-Prot

A2AII2, P21237, Q8CCH9

UniProtKB/TrEMBL

Q541P3, Q8VHH4

Related

ENSMUSP00000106673.3, ENSMUST00000111044.3

Conserved Domains (1) summary

smart00140
Location:135 → 242

NGF; Nerve growth factor (NGF or beta-NGF)
NM_007540.4 → NP_031566.4 brain-derived neurotrophic factor isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This isoform (1) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AL732477, AY057908

Consensus CDS

CCDS38193.1

UniProtKB/TrEMBL

Q8VHH4

Related

ENSMUSP00000057989.6, ENSMUST00000053317.12

Conserved Domains (1) summary

smart00140
Location:143 → 250

NGF; Nerve growth factor (NGF or beta-NGF)