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    Bsg basigin [ Mus musculus (house mouse) ]

    Gene ID: 12215, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Bsgprovided by MGI
    Official Full Name
    basiginprovided by MGI
    Primary source
    MGI:MGI:88208
    See related
    Ensembl:ENSMUSG00000023175 AllianceGenome:MGI:88208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HT-7; CD147; EMMPRIN
    Summary
    Predicted to enable signaling receptor activity and virus receptor activity. Involved in neural retina development; photoreceptor cell maintenance; and spermatogenesis. Located in several cellular components, including acrosomal membrane; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and reproductive system. Orthologous to human BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 307.0), placenta adult (RPKM 296.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bsg in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79540192..79547813)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79704358..79711979)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene granzyme M (lymphocyte met-ase 1) Neighboring gene STARR-positive B cell enhancer ABC_E10624 Neighboring gene predicted gene, 25794 Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Neighboring gene polymerase (RNA) mitochondrial (DNA directed) Neighboring gene STARR-positive B cell enhancer ABC_E3897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Expression of Basigin Gene Products Within the Pineal Gland of Mice. Tokar D, et al. Cell Mol Neurobiol, 2017 Aug. PMID 27815658, Free PMC Article
    2. Basigin expression and regulation in mouse ovary during the sexual maturation and development of corpus luteum. Chang H, et al. Mol Reprod Dev, 2004 Jun. PMID 15095333
    3. CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ. Chen R, et al. Cell Mol Immunol, 2021 Jan. PMID 31900457, Free PMC Article
    4. Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147. Chen S, et al. Biochem Biophys Res Commun, 2004 Nov 5. PMID 15464995
    5. HAb18G/CD147 enhances the secretion of matrix metalloproteinases (MMP) via cGMP/NO-sensitive capacitative calcium entry (CCE) and accordingly attenuates adhesion ability of fibroblasts. Huang Y, et al. Eur J Cell Biol, 2005 Jan. PMID 15724816

    See all (195) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD147 mediates S protein pseudovirus of SARS-CoV-2 infection and its induction of spermatogonia apoptosis.
      Title: CD147 mediates S protein pseudovirus of SARS-CoV-2 infection and its induction of spermatogonia apoptosis.
    2. CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis.
      Title: CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis.
    3. EMMPRIN promotes spheroid organization and metastatic formation: comparison between monolayers and spheroids of CT26 colon carcinoma cells.
      Title: EMMPRIN promotes spheroid organization and metastatic formation: comparison between monolayers and spheroids of CT26 colon carcinoma cells.
    4. CD147/Basigin Is Involved in the Development of Malignant Tumors and T-Cell-Mediated Immunological Disorders via Regulation of Glycolysis.
      Title: CD147/Basigin Is Involved in the Development of Malignant Tumors and T-Cell-Mediated Immunological Disorders via Regulation of Glycolysis.
    5. High-Mannose-Type Glycan of Basigin in Endothelial Cells Is Essential for the Opening of the Blood-Brain Barrier Induced by Hypoxia, Cyclophilin A, or Tumor Necrosis Factor-alpha.
      Title: High-Mannose-Type Glycan of Basigin in Endothelial Cells Is Essential for the Opening of the Blood-Brain Barrier Induced by Hypoxia, Cyclophilin A, or Tumor Necrosis Factor-α.
    6. Basigin Deficiency Induces Spontaneous Polycystic Kidney in Mice.
      Title: Basigin Deficiency Induces Spontaneous Polycystic Kidney in Mice.
    7. S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis.
      Title: S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis.
    8. Full activation of thermogenesis in brown adipocytes requires Basigin action.
      Title: Full activation of thermogenesis in brown adipocytes requires Basigin action.
    9. Reduced expression of Basigin gene products in response to chronic inflammation may contribute to vision loss.
      Title: Reduced expression of Basigin gene products in response to chronic inflammation may contribute to vision loss.
    10. CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway.
      Title: CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (108)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in decidualization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial tube morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural retina development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of matrix metallopeptidase secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mercury ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor inner segment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    basigin
    Names
    5A11/Basigin
    HT7 antigen
    basic immunoglobulin superfamily
    gp 42
    membrane glycoprotein gp42
    neurothelin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077184.1 → NP_001070652.1  basigin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001070652.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
      Source sequence(s)
      AC151828, AK002332
      Consensus CDS
      CCDS35967.1
      UniProtKB/TrEMBL
      O55107
      Related
      ENSMUSP00000136487.2, ENSMUST00000179781.8
      Conserved Domains (2) summary
      cd00096
      Location:122 → 203
      Ig; Immunoglobulin domain
      smart00410
      Location:117 → 206
      IG_like; Immunoglobulin like

    2. NM_009768.2 → NP_033898.1  basigin isoform 1 precursor

      See identical proteins and their annotated locations for NP_033898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC151828, AY089967
      Consensus CDS
      CCDS23985.1
      UniProtKB/Swiss-Prot
      P18572, Q6LDB0, Q7TSC0
      Related
      ENSMUSP00000070751.6, ENSMUST00000067036.12
      Conserved Domains (3) summary
      cd00096
      Location:238 → 319
      Ig; Immunoglobulin domain
      smart00410
      Location:233 → 322
      IG_like; Immunoglobulin like
      pfam00047
      Location:27 → 111
      ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79540192..79547813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18572.2 GenPept UniProtKB/Swiss-Prot:P18572

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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