Calb1 calbindin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calb1provided by MGI
Official Full Name: calbindin 1provided by MGI
Primary source: MGI:MGI:88248
See related: Ensembl:ENSMUSG00000028222 AllianceGenome:MGI:88248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CB; Calb; Calb-1; Brain-2
Summary: Enables calcium ion binding activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium ion binding activity involved in regulation of presynaptic cytosolic calcium ion concentration. Involved in metanephros development and retina layer formation. Acts upstream of or within locomotory behavior. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and sensory organ. Orthologous to human CALB1 (calbindin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 80.7), kidney adult (RPKM 24.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A2; 4 6.66 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (15881264..15906709)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (15881264..15906709)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distribution Patterns of Subgroups of Inhibitory Neurons Divided by Calbindin 1.
Title: Distribution Patterns of Subgroups of Inhibitory Neurons Divided by Calbindin 1.
Rabies virus infection is associated with variations in calbindin D-28K and calretinin mRNA expression levels in mouse brain tissue.
Title: Rabies virus infection is associated with variations in calbindin D-28K and calretinin mRNA expression levels in mouse brain tissue.
Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours.
Title: Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours.
Expression of Calbindin-D28K in the Developing and Adult Mouse Cochlea.
Title: Expression of Calbindin-D28K in the Developing and Adult Mouse Cochlea.
Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.
Title: Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.
Calbindin expression in adult vestibular epithelia.
Title: Calbindin expression in adult vestibular epithelia.
These data reveal that calb1 acts through a range of mechanisms underpinning both dopamine release and uptake to limit dopamine transmission in the ventral but not dorsal striatum.
Title: Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca(2+) Availability and Dopamine Transporter Function.
Upregulation of calbindin could serve as a protection to compensate for functional deficits that occur with aging.
Title: Age-Dependent Calcium-Binding Protein Expression in the Spiral Ganglion and Hearing Performance of C57BL/6J and 129/SvJ Mice.
Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect.
Title: Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect.
Calbindin-D28k protein expression was unexpectedly induced in the renal tubules of db/db diabetic mice. Results of this study showed that the inducible calbindin-D28k plays an adaptive and protective role against advanced glycation end-products-induced endoplasmic reticulum stress and the renal fibrosis signals that occurs afterwards in the proximal tubule cells.
Title: Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Calb1 (e-PCR), detects polymorphism
- UniSTS:506760

Calb1 (e-PCR), detects polymorphism
- UniSTS:141213

NoName (e-PCR)
- UniSTS:548570

D26352 (e-PCR)
- UniSTS:159222

NoName (e-PCR)
- UniSTS:224759

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
enables vitamin D binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in metanephric collecting duct development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric connecting tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric distal convoluted tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric part of ureteric bud development	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina layer formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in short-term memory	IEA Inferred from Electronic Annotation more info
involved_in short-term memory	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cuticular plate	IEA Inferred from Electronic Annotation more info
located_in cuticular plate	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in presynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in stereocilium	IEA Inferred from Electronic Annotation more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calbindin

Names: CalbindinD28K; D-28K; PCD-29; calbindin 1, 28kDa; calbindin D28; calbindin-28K; calbindin-D (28k); spot 35 protein; vitamin D-dependent calcium-binding protein, avian-type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009788.4 → NP_033918.1 calbindin

See identical proteins and their annotated locations for NP_033918.1

Status: VALIDATED

Source sequence(s)

AK038856, AK048517, BB668373

Consensus CDS

CCDS17984.1

UniProtKB/Swiss-Prot

P12658, Q545N6

UniProtKB/TrEMBL

Q8C5H2, Q8CEF3

Related

ENSMUSP00000029876.2, ENSMUST00000029876.2

Conserved Domains (2) summary

cd15902
Location:16 → 44

EFh_HEF; EF-hand motif [structural motif]

cl23634
Location:16 → 259

EFh_HEF; EF-hand, calcium binding motif, found in the hexa-EF hand proteins family