U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LOC126859601 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:14743342-14744541 [ Homo sapiens (human) ]

    Gene ID: 126859601, updated on 10-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    LOC126859601
    Gene description
    P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:14743342-14744541
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LOC126859601 in Genome Data Viewer
    Location:
    chromosome: 6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (14743111..14744310)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (14616327..14617532)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928354 Neighboring gene uncharacterized LOC102724463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24053 Neighboring gene RNA, U6 small nuclear 793, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:14676877-14677412 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:14706129-14707328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24054 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:14730658-14731857 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:14733080-14734279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16945 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:14784175-14784726 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr6:14784727-14785278 and GRCh37_chr6:14785279-14785830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:14804615-14805450 Neighboring gene Sharpr-MPRA regulatory region 9195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24056 Neighboring gene NANOG hESC enhancer GRCh37_chr6:14822305-14822806 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:14823177-14823964 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:14824752-14825538 Neighboring gene NANOG hESC enhancer GRCh37_chr6:14832080-14832596 Neighboring gene Sharpr-MPRA regulatory region 9180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24057 Neighboring gene uncharacterized LOC105374945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:14876936-14877436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:14879976-14880486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:14880487-14880996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:14883452-14884163 Neighboring gene MPRA-validated peak5674 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24062 Neighboring gene MPRA-validated peak5675 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:14958411-14958600 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:14997283-14997782 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:15013597-15013834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:15017607-15018302 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:15021466-15022336 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:15022337-15023206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24063 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:15066479-15067678 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:15077925-15078456 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:15096502-15096739 Neighboring gene ribosomal protein L6 pseudogene 17

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_084102.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      14743111..14744310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      14616327..14617532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases