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    LOC126860543 BRD4-independent group 4 enhancer GRCh37_chr8:141474198-141475397 [ Homo sapiens (human) ]

    Gene ID: 126860543, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC126860543
    Gene description
    BRD4-independent group 4 enhancer GRCh37_chr8:141474198-141475397
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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    Genomic context

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    See LOC126860543 in Genome Data Viewer
    Location:
    chromosome: 8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (140464099..140465298)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (141584263..141585462)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141474198..141475397)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 9 Neighboring gene uncharacterized LOC124902029 Neighboring gene MPRA-validated peak7188 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141274731-141275554 Neighboring gene uncharacterized LOC105375779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141282982-141283482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141309152-141309652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141309653-141310153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141312322-141312822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141312823-141313323 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:141319328-141320527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141320544-141321044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141321045-141321545 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:141341524-141342398 Neighboring gene Sharpr-MPRA regulatory region 993 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141355797-141356018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141375096-141375596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141375597-141376097 Neighboring gene Sharpr-MPRA regulatory region 8823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141458229-141458802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141458803-141459375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141468097-141468615 Neighboring gene uncharacterized LOC105375782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19579 Neighboring gene MPRA-validated peak7190 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141518766-141518946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141537549-141538050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141538051-141538550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141554768-141555545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141559982-141560482 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:141569579-141570778 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:141567119-141568318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141578119-141578876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28030 Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141603574-141604074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141607590-141608092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141619067-141620038 Neighboring gene MAGE-like protein 2 Neighboring gene argonaute RISC catalytic component 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141634221-141635220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141635221-141636221

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_085043.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      140464099..140465298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      141584263..141585462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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