U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LOC127272340 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:2011491-2011992 [ Homo sapiens (human) ]

    Gene ID: 127272340, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    LOC127272340
    Gene description
    OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:2011491-2011992
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LOC127272340 in Genome Data Viewer
    Location:
    chromosome: 2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (2007719..2008220)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (2017832..2018333)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (2011491..2011992)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1829865-1830422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1842467-1842968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1845570-1846224 Neighboring gene uncharacterized LOC107985838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1846879-1847533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1847534-1848187 Neighboring gene myelin transcription factor 1 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:1868997-1869620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1878441-1878941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1969195-1969716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:1977845-1978345 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:1990006-1990664 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:1990665-1991322 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:2010989-2011490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2028319-2028820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2028821-2029320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2029757-2030573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2149801-2150324 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:2150847-2151369 Neighboring gene NANOG hESC enhancer GRCh37_chr2:2252484-2253019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2276633-2277264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:2295761-2296549 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:2297557-2298056 Neighboring gene MYT1L antisense RNA 1 Neighboring gene uncharacterized LOC105373389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11105

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_094191.1 

      Range
      101..602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      2007719..2008220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      2017832..2018333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases