U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LOC127274407 H3K27ac hESC enhancer GRCh37_chr2:111434896-111435816 [ Homo sapiens (human) ]

    Gene ID: 127274407, updated on 12-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    LOC127274407
    Gene description
    H3K27ac hESC enhancer GRCh37_chr2:111434896-111435816
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer, silencer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LOC127274407 in Genome Data Viewer
    Location:
    chromosome: 2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110677319..110678239)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (111100232..111101152)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111434896..111435816)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16371 Neighboring gene uncharacterized LOC105373554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111435817-111436737 Neighboring gene small nucleolar RNA, C/D box 132 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111445059-111446030 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111446031-111447002 Neighboring gene Sharpr-MPRA regulatory region 12654 Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase Neighboring gene uncharacterized LOC124906064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16374 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:111510337-111510838 Neighboring gene NANOG hESC enhancer GRCh37_chr2:111529706-111530207 Neighboring gene acyl-CoA oxidase like Neighboring gene ReSE screen-validated silencer GRCh37_chr2:111553982-111554181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:111556532-111557731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111558229-111558834 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:111559681-111560360 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111570488-111570988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111594132-111595120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16375 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111616831-111617348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111623769-111624474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111624475-111625179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111626664-111627274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111631628-111632251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111634418-111635282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111661014-111661514 Neighboring gene ribosomal protein L5 pseudogene 9

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See Variation Viewer (GRCh37.p13)

    General gene information

    Go to the top of the page Help

    Other Names

    • ATAC-STARR-seq lymphoblastoid silent region 11864

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_096257.1 

      Range
      101..1021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      110677319..110678239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      111100232..111101152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases