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    MAGEB10 MAGE family member B10 [ Homo sapiens (human) ]

    Gene ID: 139422, updated on 2-Nov-2024

    Summary

    Official Symbol
    MAGEB10provided by HGNC
    Official Full Name
    MAGE family member B10provided by HGNC
    Primary source
    HGNC:HGNC:25377
    See related
    Ensembl:ENSG00000177689 MIM:300761; AllianceGenome:HGNC:25377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010]
    Expression
    Restricted expression toward testis (RPKM 1.6) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAGEB10 in Genome Data Viewer
    Location:
    Xp21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (27807990..27823014)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (27398790..27413814)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (27826107..27841131)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:27480372-27481571 Neighboring gene NANOG hESC enhancer GRCh37_chrX:27488313-27488871 Neighboring gene protein phosphatase 4 regulatory subunit 3C Neighboring gene DDB1 and CUL4 associated factor 8 like 2 Neighboring gene radixin pseudogene 2 Neighboring gene RDX pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:27818821-27819333 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:27819334-27819845 Neighboring gene MAGE family member B18 pseudogene Neighboring gene MAGE family member B3 pseudogene Neighboring gene MAGE family member B4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32965, MGC120394

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    melanoma-associated antigen B10
    Names
    MAGE family testis and tumor-specific protein
    MAGE-B10 antigen
    melanoma antigen family B, 10
    melanoma antigen family B10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017094.1 RefSeqGene

      Range
      5007..20031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182506.3NP_872312.2  melanoma-associated antigen B10

      See identical proteins and their annotated locations for NP_872312.2

      Status: REVIEWED

      Source sequence(s)
      AC112492, AK057527, BC101308
      Consensus CDS
      CCDS35221.1
      UniProtKB/Swiss-Prot
      Q494Y6, Q494Y7, Q96LZ2, Q9BZ78
      Related
      ENSP00000368304.1, ENST00000356790.2
      Conserved Domains (2) summary
      pfam01454
      Location:118286
      MAGE; MAGE family
      pfam12440
      Location:593
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      27807990..27823014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      27398790..27413814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)