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    E1 E1 [ human papillomavirus 18 ]

    Gene ID: 1489084, updated on 18-Aug-2023

    Summary

    Gene symbol
    E1
    Gene description
    E1
    Locus tag
    HpV18gp3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    human papillomavirus 18
    Lineage
    Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus
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    Genomic context

    Sequence:
    NC_001357.1 (914..2887)

    NC_001357.1Genomic Context describing neighboring genes Neighboring gene E6 protein Neighboring gene E7 protein Neighboring gene E2 protein Neighboring gene E4 protein Neighboring gene E5 protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General protein information

    Preferred Names
    E1
    NP_040312.1
    • E1; The Papillomaviriuses are icosahedral dsDNA viruses that encode 7 early proteins, E1 to E7, and 2 late structural proteins L1 and L2. Host infection by members of the papillomaviruses gives rise to warts and cancer in some instances. The E1 helicase protein is an ATP-dependent DNA helicase that facilitates the inititiation of viral DNA replication through its interactions with the viral E2 protein. The E1-E2 complex binds to the viral origin of replication where E1 acts to unwind the DNA and E2 acts as a transcriptional activator.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001357.1 Reference assembly

      Range
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040312.1 E1 protein [human papillomavirus 18]

      See identical proteins and their annotated locations for NP_040312.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P06789, Q84181
      UniProtKB/TrEMBL
      Q80B72
      Conserved Domains (3) summary
      PHA02774
      Location:1657
      PHA02774; E1; Provisional
      pfam00524
      Location:1141
      PPV_E1_N; E1 Protein, N terminal domain
      cl24009
      Location:217648
      Parvo_NS1; Parvovirus non-structural protein NS1
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