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    GAMMAHV.ORF50 transcriptional activator [ Murid gammaherpesvirus 4 (Murine herpesvirus 68) ]

    Gene ID: 1497167, updated on 18-Aug-2023

    Summary

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    Gene symbol
    GAMMAHV.ORF50
    Gene description
    transcriptional activator
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Murid gammaherpesvirus 4 (strain: WUMS)
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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    Genomic context

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    Sequence:
    NC_001826.2 (67908..69377)

    NC_001826.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene glycoprotein 150 Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001826.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epigenetic modification of Rta (ORF50) promoter is not responsible for distinct reactivation patterns of murine gammaherpesviruses. Lapuníková B, et al. Acta Virol, 2015 Dec. PMID 26666189
    2. Up-regulation of Murid herpesvirus 4 ORF50 by hypoxia: possible implication for virus reactivation from latency. Polcicova K, et al. Virus Res, 2008 Mar. PMID 18221814
    3. Control of Rta expression critically determines transcription of viral and cellular genes following gammaherpesvirus infection. Hair JR, et al. J Gen Virol, 2007 Jun. PMID 17485528, Free PMC Article
    4. Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication. Allen RD 3rd, et al. Virology, 2007 Sep 1. PMID 17477952, Free PMC Article
    5. The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression. Foreman HC, et al. J Biol Chem, 2017 Sep 29. PMID 28821622, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest MHV68 RTA specifically recognizes and recruits activated (phosphorylated at Tyr705) host Stat3 during lytic phase of infection; Stat3, once phosphorylated at Tyr705, avidly binds consensus target site in promoters of regulated genes. (MHV68 = murine gammaherpesvirus 68; RTA = replication and transcription activator coded for by ORF50; Stat3 = signal transducer and activator of transcription 3 protein)
      Title: The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression.
    2. Epigenetic modification of Rta (ORF50) promoter is not responsible for virus reactivation.
      Title: Epigenetic modification of Rta (ORF50) promoter is not responsible for distinct reactivation patterns of murine gammaherpesviruses.
    3. This study identified ORF48 as an RTA-responsive gene and showed that ORF48 is important for Murine herpesvirus 68 replication both in vitro and in vivo.
      Title: Murine Gammaherpesvirus 68 ORF48 Is an RTA-Responsive Gene Product and Functions in both Viral Lytic Replication and Latency during In Vivo Infection.
    4. Murine gammaherpesvirus 68 subverts early NF-kappaB activation and cytokine production through vrial RTA-induced RelA degradation.
      Title: Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation.
    5. ORF49 promotes viral replication and is a derepressor for RTA.
      Title: The virion-associated open reading frame 49 of murine gammaherpesvirus 68 promotes viral replication both in vitro and in vivo as a derepressor of RTA.
    6. study reports orf36 facilitated expression of RTA, an immediate early MHV68 gene and DNA synthesis during infection of primary macrophages; H2AX expression supported efficient RTA transcription and phosphorylated H2AX associated with RTA promoter
      Title: Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX.
    7. The authors engineered RTA-responsive element-deleted viruses and demonstrated in the context of the viral genome that one of these elements mediates the RTA-dependent activation of an essential lytic gene, ORF18, during de novo infection.
      Title: Replication and transcription activator (RTA) of murine gammaherpesvirus 68 binds to an RTA-responsive element and activates the expression of ORF18.
    8. HDAC3, HDAC4, and NCoR binding to the promoter of gene 50 and enhances MHV68 lytic replication.
      Title: Histone deacetylases and the nuclear receptor corepressor regulate lytic-latent switch gene 50 in murine gammaherpesvirus 68-infected macrophages.
    9. The expression of ORF50, a crucial gene responsible for switch from latency to lytic virus replication, was induced upon the exposure of NB-78 cells to hypoxia.
      Title: Up-regulation of Murid herpesvirus 4 ORF50 by hypoxia: possible implication for virus reactivation from latency.
    10. v-cyclin expression is driven by a promoter responsive to the major viral lytic transactivator, Rta, encoded by orf 50.
      Title: Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replication.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    transcriptional activator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001826.2 Reference assembly

      Range
      67908..69377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_044887.3 transcriptional activator [Murid gammaherpesvirus 4]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      P88988, Q9QAI4
      Conserved Domains (1) summary
      pfam03326
      Location:1 → 414
      Herpes_TAF50; Herpesvirus transcription activation factor (transactivator)
    Nucleotide Protein
    Heading Accession and Version

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