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    CTSB cathepsin B [ Homo sapiens (human) ]

    Gene ID: 1508, updated on 3-Nov-2024

    Summary

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    Official Symbol
    CTSBprovided by HGNC
    Official Full Name
    cathepsin Bprovided by HGNC
    Primary source
    HGNC:HGNC:2527
    See related
    Ensembl:ENSG00000164733 MIM:116810; AllianceGenome:HGNC:2527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KWE; APPS; CPSB; RECEUP
    Summary
    This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
    Expression
    Broad expression in thyroid (RPKM 602.1), appendix (RPKM 198.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CTSB in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (11842524..11868087, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (7872212..7897789)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (11700033..11725596, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379243 Neighboring gene Sharpr-MPRA regulatory region 11637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:11657524-11658167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:11658297-11659039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:11659040-11659781 Neighboring gene SUB1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18943 Neighboring gene farnesyl-diphosphate farnesyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:11705639-11706333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11706334-11707027 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:11707258-11707440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:11710619-11711226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11714811-11715344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11734657-11735174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11735175-11735690 Neighboring gene CRISPRi-validated cis-regulatory element chr8.429 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:11748634-11748817 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11759741-11760242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:11768552-11769052 Neighboring gene olfactory receptor family 7 subfamily E member 158 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 161 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B. Redzynia I, et al. J Biol Chem, 2008 Aug 15. PMID 18515357
    2. IGFBP-4 anti-angiogenic and anti-tumorigenic effects are associated with anti-cathepsin B activity. Moreno MJ, et al. Neoplasia, 2013 May. PMID 23633927, Free PMC Article
    3. In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells. Mehtani S, et al. J Biol Chem, 1998 May 22. PMID 9582368
    4. Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion. Michallet MC, et al. Blood, 2003 Nov 15. PMID 12893746
    5. Molecular regulation of human cathepsin B: implication in pathologies. Yan S, et al. Biol Chem, 2003 Jun. PMID 12887051

    See all (418) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Significance of Cathepsin B in Mediating Radiation Resistance in Colon Carcinoma Cell Line (Caco-2).
      Title: The Significance of Cathepsin B in Mediating Radiation Resistance in Colon Carcinoma Cell Line (Caco-2).
    2. The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review.
      Title: The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review.
    3. Correlation Analysis of CTSB Promoter Polymorphism and Function in Patients with Dilated Cardiomyopathy.
      Title: Correlation Analysis of CTSB Promoter Polymorphism and Function in Patients with Dilated Cardiomyopathy.
    4. Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes.
      Title: Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes.
    5. Research progress of cathepsin B in brain aging and Alzheimer's diseases.
      Title: Research progress of cathepsin B in brain aging and Alzheimer's diseases.
    6. Association of AXIN1 rs12921862 C/A and rs1805105 G/A and CTSB rs12898 G/A polymorphisms with papillary thyroid carcinoma: A case-control study.
      Title: Association of AXIN1 rs12921862 C/A and rs1805105 G/A and CTSB rs12898 G/A polymorphisms with papillary thyroid carcinoma: A case-control study.
    7. Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance.
      Title: Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance.
    8. Cathepsin B-A Neuronal Death Mediator in Alzheimer's Disease Leading to Neurodegeneration.
      Title: Cathepsin B-A Neuronal Death Mediator in Alzheimer's Disease Leading to Neurodegeneration.
    9. Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation.
      Title: Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation.
    10. Cathepsin B p.Gly284Val Variant in Parkinson's Disease Pathogenesis.
      Title: Cathepsin B p.Gly284Val Variant in Parkinson's Disease Pathogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (252)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Keratolytic winter erythema
    MedGen: C0406756 OMIM: 148370 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-02-08)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-02-08)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection upregulates cathepsin B, cystatin B, and cystatin C in the frontal white matter of patients with HIV-Associated Neurocognitive Disorders PubMed
    HIV-1 infection in macrophages decreases Cathepsin B and MMP9 interactions PubMed
    HIV-1 infection upregulates cathepsin B (CTSB) in microglia and CHME-5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of cathepsin B (CTSB) in human B cells PubMed
    env HIV-1 gp120-treated vaginal epithelial cells show downregulation of cathepsin B (CTSB) expression as compared to untreated control PubMed
    Pr55(Gag) gag Macrophages and HEK293T cells deficient in cathepsin B (CTSB) fail to release HIV-1 Gag pseudoparticles into the extracellular environment PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of cathepsin B (CTSB) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables proteoglycan binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to thyroid hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in collagen catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in decidualization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in endolysosome lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of peptidase inhibitor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cathepsin B
    Names
    APP secretase
    amyloid precursor protein secretase
    cathepsin B1
    cysteine protease
    epididymis secretory sperm binding protein
    keratolytic winter erythema (Oudtshoorn skin disease)
    NP_001304166.1
    NP_001371643.1
    NP_001371652.1
    NP_001371653.1
    NP_001371654.1
    NP_001371655.1
    NP_001371656.1
    NP_001371657.1
    NP_001899.1
    NP_680090.1
    NP_680091.1
    NP_680092.1
    NP_680093.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009217.2 RefSeqGene

      Range
      5051..30614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001317237.2 → NP_001304166.1  cathepsin B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon in its 5' coding region and uses an alternate translation start site compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.
      Source sequence(s)
      AA516096, AC069185, AK130184, BX647765, DC386022
      UniProtKB/TrEMBL
      Q5HYG5
      Related
      ENSP00000504808.1, ENST00000678629.1
      Conserved Domains (1) summary
      cd02620
      Location:25 → 204
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

    2. NM_001384714.1 → NP_001371643.1  cathepsin B isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Both variants 1 and 7 encode the same protein.
      Source sequence(s)
      AC025857, AC069185
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000503674.1, ENST00000678145.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    3. NM_001384723.1 → NP_001371652.1  cathepsin B isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Both variants 1 and 8 encode the same protein.
      Source sequence(s)
      AC025857, AC069185
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000503435.1, ENST00000677819.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    4. NM_001384724.1 → NP_001371653.1  cathepsin B isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Both variants 1 and 9 encode the same protein.
      Source sequence(s)
      AC025857, AC069185
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000504797.1, ENST00000677650.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    5. NM_001384725.1 → NP_001371654.1  cathepsin B isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Both variants 1 and 10 encode the same protein.
      Source sequence(s)
      AC025857, AC069185
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000503513.1, ENST00000678357.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    6. NM_001384726.1 → NP_001371655.1  cathepsin B isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Both variants 1 and 11 encode the same protein.
      Source sequence(s)
      AC025857, AC069185
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000434217.1, ENST00000534510.6
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    7. NM_001384727.1 → NP_001371656.1  cathepsin B isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Both variants 1 and 12 encode the same protein.
      Source sequence(s)
      AC025857, AC069185
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000503174.1, ENST00000677418.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    8. NM_001384728.1 → NP_001371657.1  cathepsin B isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Both variants 1 and 13 encode the same protein.
      Source sequence(s)
      AC025857, AC069185
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000503487.1, ENST00000678929.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    9. NM_001908.5 → NP_001899.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1). Variants 1-5, and 7-13 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK130184, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000345672.5, ENST00000353047.11
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    10. NM_147780.4 → NP_680090.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_680090.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK130184, BG770805, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000503078.1, ENST00000677544.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    11. NM_147781.4 → NP_680091.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_680091.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK130184, AL543654, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000342070.3, ENST00000345125.8
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    12. NM_147782.4 → NP_680092.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_680092.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK130184, BG770805, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000503280.1, ENST00000678242.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    13. NM_147783.4 → NP_680093.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_680093.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK092070, AK130184
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      B3KQR5, B3KRR5, P07858, Q503A6, Q96D87
      UniProtKB/TrEMBL
      A0A024R374, A0A7P0NGZ6, A8K2H4
      Related
      ENSP00000503858.1, ENST00000679051.1
      Conserved Domains (2) summary
      cd02620
      Location:81 → 328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:26 → 65
      Propeptide_C1; Peptidase family C1 propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      11842524..11868087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      1479972..1505569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      7872212..7897789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07858.3 GenPept UniProtKB/Swiss-Prot:P07858

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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