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    Id3 inhibitor of DNA binding 3 [ Mus musculus (house mouse) ]

    Gene ID: 15903, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Id3provided by MGI
    Official Full Name
    inhibitor of DNA binding 3provided by MGI
    Primary source
    MGI:MGI:96398
    See related
    Ensembl:ENSMUSG00000007872 AllianceGenome:MGI:96398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Idb3; Hlh462; bHLHb25
    Summary
    Enables several functions, including bHLH transcription factor binding activity; leptomycin B binding activity; and transcription regulator inhibitor activity. Involved in several processes, including negative regulation of myoblast differentiation; notochord development; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to leptomycin B; negative regulation of macromolecule biosynthetic process; and negative regulation of osteoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and sensory organ. Used to study Sjogren's syndrome. Orthologous to human ID3 (inhibitor of DNA binding 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 274.3), stomach adult (RPKM 262.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Id3 in Genome Data Viewer
    Location:
    4 D3; 4 68.34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135871133..135872703)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136143822..136145392)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2130 Neighboring gene ribosomal protein L11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135627400-135627509 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135643248-135643431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135644875-135644984 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135644986-135645252 Neighboring gene STARR-positive B cell enhancer ABC_E6236 Neighboring gene STARR-positive B cell enhancer ABC_E4687 Neighboring gene STARR-seq mESC enhancer starr_11745 Neighboring gene predicted gene, 42329 Neighboring gene STARR-positive B cell enhancer ABC_E10267 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135727983-135728166 Neighboring gene STARR-positive B cell enhancer ABC_E3530 Neighboring gene STARR-seq mESC enhancer starr_11747 Neighboring gene STARR-positive B cell enhancer ABC_E6237 Neighboring gene STARR-positive B cell enhancer ABC_E427 Neighboring gene E2F transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_11748 Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene STARR-seq mESC enhancer starr_11750

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells. Verykokakis M, et al. PLoS One, 2010 Feb 19. PMID 20174563, Free PMC Article
    2. Quantitative classification of chromatin dynamics reveals regulators of intestinal stem cell differentiation. Raab JR, et al. Development, 2020 Jan 3. PMID 31862843, Free PMC Article
    3. Null mutation of the transcription factor inhibitor of DNA binding 3 (id3) affects spermatozoal motility parameters and epididymal gene expression in mice. Carroll M, et al. Biol Reprod, 2011 Apr. PMID 21148110, Free PMC Article
    4. Developmental expression patterns and localization of DNA-binding protein inhibitor (Id3) in the mouse retina. Yeung SC, et al. Neuroreport, 2005 May 12. PMID 15858404
    5. Cutting Edge: Dynamic Expression of Id3 Defines the Stepwise Differentiation of Tissue-Resident Regulatory T Cells. Sullivan JM, et al. J Immunol, 2019 Jan 1. PMID 30518568, Free PMC Article

    See all (292) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The nuclear factor ID3 endows macrophages with a potent anti-tumour activity.
      Title: The nuclear factor ID3 endows macrophages with a potent anti-tumour activity.
    2. Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke.
      Title: Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke.
    3. Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.
      Title: Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.
    4. Id3 expression identifies CD4(+) memory Th1 cells.
      Title: Id3 expression identifies CD4(+) memory Th1 cells.
    5. Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia.
      Title: Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia.
    6. ID1 and ID3 are Negative Regulators of TGFbeta2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.
      Title: ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.
    7. Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.
      Title: Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.
    8. Interleukin-21-mediated suppression of the Pax3-Id3 pathway exacerbates the development of Sjogren's syndrome via follicular helper T cells.
      Title: Interleukin-21-mediated suppression of the Pax3-Id3 pathway exacerbates the development of Sjögren's syndrome via follicular helper T cells.
    9. Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
      Title: Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
    10. Idgenes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.
      Title: Idgenes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.
    Submit: New GeneRIF Correction See all GeneRIFs (88)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables leptomycin B binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leptomycin B IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in central nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in metanephros development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in notochord development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in odontogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding protein inhibitor ID-3
    Names
    ID-like protein inhibitor HLH 462
    inhibitor of differentiation 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429353.1 → NP_001416282.1  DNA-binding protein inhibitor ID-3

      Status: VALIDATED

      Source sequence(s)
      AL935264
      UniProtKB/Swiss-Prot
      P41133
      UniProtKB/TrEMBL
      Q545W1

    2. NM_008321.3 → NP_032347.1  DNA-binding protein inhibitor ID-3

      See identical proteins and their annotated locations for NP_032347.1

      Status: VALIDATED

      Source sequence(s)
      AL935264
      Consensus CDS
      CCDS18800.1
      UniProtKB/Swiss-Prot
      P41133
      UniProtKB/TrEMBL
      Q545W1
      Related
      ENSMUSP00000008016.3, ENSMUST00000008016.3
      Conserved Domains (1) summary
      cd19693
      Location:23 → 83
      bHLH_dnHLH_ID3; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135871133..135872703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41133.1 GenPept UniProtKB/Swiss-Prot:P41133

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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