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Ifng interferon gamma [ Mus musculus (house mouse) ]

Gene ID: 15978, updated on 2-Nov-2024

Summary

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Official Symbol: Ifngprovided by MGI
Official Full Name: interferon gammaprovided by MGI
Primary source: MGI:MGI:107656
See related: Ensembl:ENSMUSG00000055170 AllianceGenome:MGI:107656
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifg; If2f; IFN-g
Summary: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

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See Ifng in Genome Data Viewer

Location:: 10 D2; 10 66.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (118276951..118281799)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (118441046..118445894)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-37 exacerbates liver inflammation and promotes IFN-gamma production in NK cells.
Title: Interleukin-37 exacerbates liver inflammation and promotes IFN-γ production in NK cells.
Nuclear HMGB1 is critical for CD8 T cell IFN-gamma production and anti-tumor immunity.
Title: Nuclear HMGB1 is critical for CD8 T cell IFN-γ production and anti-tumor immunity.
Sepsis Impairs IFN-gamma Production in CD8 T Cells through Changes in Local Chromatin Landscape.
Title: Sepsis Impairs IFN-γ Production in CD8 T Cells through Changes in Local Chromatin Landscape.
Age-dependent natural killer cell and interferon gamma deficits contribute to severe pertussis in infant mice.
Title: Age-dependent natural killer cell and interferon γ deficits contribute to severe pertussis in infant mice.
Lack of the IFN-gamma signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions.
Title: Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions.
Foxp3[+] Treg control allergic skin inflammation by restricting IFN-gamma-driven neutrophilic infiltration and NETosis.
Title: Foxp3(+) Treg control allergic skin inflammation by restricting IFN-γ-driven neutrophilic infiltration and NETosis.
Comparative single-cell analysis reveals IFN-gamma as a driver of respiratory sequelae after acute COVID-19.
Title: Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae after acute COVID-19.
Reappraising the Role of T Cell-Derived IFN-gamma in Restriction of Mycobacterium tuberculosis in the Murine Lung.
Title: Reappraising the Role of T Cell-Derived IFN-γ in Restriction of Mycobacterium tuberculosis in the Murine Lung.
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification.
Title: A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification.
Endogenous IFN-gamma facilitates Pneumocystis infection and downregulates carbohydrate receptors in CD4[+] T cell-depleted mice.
Title: Endogenous IFN-γ facilitates Pneumocystis infection and downregulates carbohydrate receptors in CD4(+) T cell-depleted mice.

Submit: New GeneRIF Correction See all GeneRIFs (1164)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ifng (e-PCR), detects polymorphism
- UniSTS:257043

K00083 (e-PCR)
- UniSTS:160031

PMC108010P1 (e-PCR)
- UniSTS:270128

Ifng (e-PCR), detects polymorphism
- UniSTS:463945

Il12b (e-PCR), detects polymorphism
- UniSTS:463947

PMC122924P1 (e-PCR)
- UniSTS:270415

NoName (e-PCR)
- UniSTS:492886

PMC152071P1 (e-PCR)
- UniSTS:271200

Ifng (e-PCR), detects polymorphism
- UniSTS:143461

Ifng (e-PCR), detects polymorphism
- UniSTS:143462

PMC187318P1 (e-PCR)
- UniSTS:271723

PMC356969P1 (e-PCR)
- UniSTS:273271

PMC356969P2 (e-PCR)
- UniSTS:273275

PMC356969P3 (e-PCR)
- UniSTS:273276

PMC356969P4 (e-PCR)
- UniSTS:273277

PMC356969P8 (e-PCR)
- UniSTS:273281

PMC356970P1 (e-PCR)
- UniSTS:273283

PMC143270P1 (e-PCR)
- UniSTS:270997

PMC112570P1 (e-PCR)
- UniSTS:270234

Ifng (e-PCR), detects polymorphism
- UniSTS:466090

PMC154013P3 (e-PCR)
- UniSTS:271282

D10Mit24 (e-PCR), detects polymorphism
- UniSTS:126144

PMC127750P2 (e-PCR)
- UniSTS:270559

PMC97984P1 (e-PCR)
- UniSTS:273661

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables type II interferon receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adaptive immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in astrocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-18	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of amyloid-beta clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glomerular mesangial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myelination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tau-protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuroinflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation by host of viral process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MHC class II biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MHC class II biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of NMDA glutamate receptor activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of amyloid-beta formation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of amyloid-beta formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcidiol 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular respiration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of core promoter binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fructose 1,6-bisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-23 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of iron ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of signaling receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, cholinergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vitamin D biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in response to tacrolimus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to virus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in type II interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in type III interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon gamma

Names: IFN-gamma; gamma interferon; interferon 2f

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.